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Title: Discovery, molecular modeling and biological evaluation of 1,3,5-triaril-pyrazole derivates as novel Estrogen Receptor Modulators
Authors: López Rojas, Priscila
Amesty, Ángel
Fernández Sánchez, Yeray
Guerra Rodríguez, Miguel
Santana Viera, Sergio 
Recio Cruz, Carlota Pilar 
Guerra Hernández, Carlos Borja 
Estévez Braun,Ana 
Fernández Pérez, Leandro Fco 
UNESCO Clasification: 3209 Farmacología
Keywords: Estrogens
Biological evaluation
Issue Date: 2023
Publisher: British Pharmacological Society
Conference: 19th World Congress of Basic and Clinical Pharmacology 
Abstract: The biological actions of estrogens are mediated by estrogen binding to one of two specific estrogen receptors (ERs), ERαand ERβ. The ERs,which belong to the nuclear receptor superfamily of ligand-regulated transcription factors, are products of different genes and exhibit tissue- andcell-type specific expression. Clinically relevant, ERs are currently considered relevant drug targets for prevention and/or treatment of several dis-eases (from cancer, metabolic and cardiovascular, inflammation, and osteoporosis to neurodegeneration). In this work, new derivatives of1,3,5-triaril-pyrazoles were designed, synthesized and evaluated in vitro as Estrogen Receptor Modulators.
ISSN: 0007-1188
Source: Brithis Journal of Pharmacology [ISSN 0007-1188, eISSN 1476-5381 ], v. 180 (1), p. 580-581, (Julio 2023)
Appears in Collections:Póster de congreso
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