Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/127446
Título: Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort
Autores/as: Shyam, Sangeetha
García Gavilán, Jesús Francisco
Paz Graniel, Indira
Gaforio, José J.
Martínez González, Miguel Ángel
Corella, Dolores
Martínez, J. Alfredo
Alonso Gómez, Ángel M.
Wärnberg, Julia
Vioque, Jesús
Romaguera, Dora
López Miranda, José
Estruch, Ramon
Tinahones, Francisco J.
Lapetra, José
Serra Majem, Lluis 
Bueno Cavanillas, Aurora
Tur, Josep A.
Sánchez, Vicente Martín
Pintó, Xavier
Matía-Martín, Pilar
Vidal, Josep
Vázquez, Clotilde
Daimiel, Lidia
Ros, Emilio
Fernandez Aranda, Fernando
Nishi, Stephanie K.
Garcia Regata, Oscar
Toledo, Estefania
Asensio, Eva M.
Castañer, Olga
Garcia Rios, Antonio
Torres-Collado, Laura
Gómez Gracia, Enrique
Zulet, M. Angeles
Ruiz, Nuria Goñi
Casas, Rosa
Cano Ibáñez, Naomi
Tojal Sierra, Lucas
Gómez Perez, A. M.
Sorlí, Jose V.
Cinza Sanjurjo, Sergio
Martín Peláez, Sandra
Peña Orihuela, Patricia J.
Oncina Canovas, Alejandro
Perez Araluce, Rafael
Zomeño, María Dolores
Chaplin, Alice
Delgado Rodríguez, Miguel
Babio, Nancy
Fitó, Montserrat
Salas Salvadó, Jordi
Clasificación UNESCO: 32 Ciencias médicas
Palabras clave: Central Obesity
Covid-19
Obesity
Older Adults
Weight Loss
Fecha de publicación: 2023
Publicación seriada: BMC Medicine 
Resumen: Background: Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk. Methods: This analysis included 6874 men and women (aged 55–75 years) with overweight/obesity and metabolic syndrome in the PREDIMED-Plus lifestyle intervention trial for cardiovascular risk reduction. Body weight, body-mass-index (BMI), waist circumference, waist-to-height ratio (WHtR), and a body shape index (ABSI) were measured at baseline and annual follow-up visits. COVID-19 was ascertained by an independent Event Committee until 31 December 2021. Cox regression models were fitted to evaluate the risk of COVID-19 incidence based on baseline adiposity parameters measured 5–6 years before the pandemic and their changes at the visit prior to censoring. Results: At the time of censoring, 653 incident COVID-19 cases occurred. Higher baseline body weight, BMI, waist circumference, and WHtR were associated with increased COVID-19 risk. During the follow-up, every unit increase in body weight (HRadj (95%CI): 1.01 (1.00, 1.03)) and BMI (HRadj: 1.04 (1.003, 1.08)) was associated with increased COVID-19 risk. Conclusions: In older adults with overweight/obesity, clinically significant weight loss may protect against COVID-19.
URI: http://hdl.handle.net/10553/127446
DOI: 10.1186/s12916-023-03079-z
Fuente: BMC Medicine [EISSN 1741-7015], v. 21 (1), (Diciembre 2023).
Colección:Artículos
Vista completa

Google ScholarTM

Verifica

Altmetric


Comparte



Exporta metadatos



Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.