Please use this identifier to cite or link to this item:
Title: Targeting cytokine storm in COVID-19: A role of online hemodiafiltration with asymmetric cellulose triacetate in maintenance hemodialysis patients-a report of 10 cases
Authors: De La Flor, J.C.
Valga Amado, Ernesto Francisco 
Marschall, Alexander
Monzón Vázquez, Tania Raquel 
Albarracín, Cristina
Ruiz, Elisa
Rodeles, Miguel
Editors: Vera, Manel
UNESCO Clasification: 32 Ciencias médicas
320506 Nefrología
Keywords: COVID-19
Maintenance hemodialysis
Issue Date: 2021
Journal: Case Reports in Nephrology 
Abstract: Early reports have suggested that maintenance hemodialysis (MHD) patients could be more susceptible to a severe course of COVID-19. Among the therapeutic approaches, the use of drugs that reduce the cytokine storm characteristic of this disease has been proposed. Some dialyzers, such as the new generation of asymmetric cellulose triacetate (ATA) membranes, could favor the effective elimination of medium-sized molecules and other inflammatory mediators. In this case series, we describe in depth the clinical, analytical, and radiological details, therapeutic aspects, and outcomes of the case series of 10 MHD patients of our dialysis unit, who tested positive for SARS-CoV-2 from 5 October to 30 November 2020. Furthermore, we evaluate the removal of hyperinflammatory parameters with the ATA membrane in postdilution online hemodiafiltration (OL-HDF) in these patients through a variety of biomarkers of systemic inflammation from the diagnosis until stripping. Biochemical blood analysis was carried out at baseline and at days 7 and 14 after diagnosis, respectively. 50% of the patients presented COVID-19 pneumonia and required hospital admission. Median hospitalization time was 21 days. A total of 4 patients developed severe pneumonia (3 of them died) and 1 patient developed moderate pneumonia. Patients who died (n = 3) were more likely to present bilateral pneumonia (100% vs 14.3%) at diagnosis and less reduction in interleukin 6 (IL-6) at day 14, as compared to those who survived. The use of the ATA membrane could be considered a therapeutic option, due to its immunomodulatory effect in MHD patients with SARS-CoV-2 infection, especially at the beginning of the disease, where the inflammatory component is predominant.
ISSN: 2090-665X
DOI: 10.1155/2021/5575928
Source: Case Reports in Nephrology[2090-665x], vol. 2021: 5575928 (Marzo 2021)
Appears in Collections:Artículos
Adobe PDF (1,36 MB)
Show full item record


checked on Dec 3, 2023

Google ScholarTM




Export metadata

Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.