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Title: 25OHVitamin D Levels in a Canarian Pediatric Population with and without Type 1 Diabetes: The Role of Acidosis
Authors: Novoa Medina,Yeray 
Barreiro Bautista, Marta
Perdomo Quinteiro, Marta
González Martín, Jesús María
Quinteiro González, Sofía
Domínguez, Ángela
Cabrera, María
López, Sara
Pavlovic, Svetlana
Wägner, Anna Maria Claudia 
UNESCO Clasification: 32 Ciencias médicas
320110 Pediatría
320502 Endocrinología
Keywords: 25Ohvitamin D
Type 1 Diabetes
Issue Date: 2023
Journal: Nutrients 
Abstract: The role of Vitamin D in the development of type 1 diabetes (T1D) is controversial. The Canary Islands have the highest incidence of childhood-onset T1D in Spain and one of the highest in Europe. We aimed to evaluate 25OHVitamin D concentrations in a Canarian pediatric population, to assess the existence of seasonal variation, to study their association with T1D, and to evaluate the role of acidosis in its levels. In a retrospective, case-control study, we obtained data from 146 T1D patients (<15 years of age) and 346 control children; 25OHVitamin D concentrations were assessed in serum by automatic ChemiLuminescence ImmunoAssay technology. We found significantly higher 25OHVitamin D levels in the summer and autumn months and an inverse correlation between T1D and age; 25OHVitamin D sufficiency was similar in both groups (44.5% vs. 45.1%), with significant differences in the percentage of patients presenting vitamin D deficiency (11.6% (T1D) vs. 16.4% (controls)). When stratified according to the presence of ketoacidosis at sampling, only patients with acidosis showed lower 25OHVitamin D concentrations than controls. Despite its subtropical geographic location, Vitamin D deficiency is frequent in children in Gran Canaria, and 25OHVitamin D concentrations show seasonal variation. After adjusting for acidosis, no differences were found between children with and without T1D.
ISSN: EISSN 2072-6643
DOI: 10.3390/nu15133067
Source: Nutrients, [EISSN 2072-6643], v .15 (13), (Julio 2023)
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