Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/123970
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dc.contributor.authorKohls, Men_US
dc.contributor.authorFreisling, Hen_US
dc.contributor.authorCharvat, Hen_US
dc.contributor.authorSoerjomataram, Ien_US
dc.contributor.authorViallon, Ven_US
dc.contributor.authorDávila Batista, Verónicaen_US
dc.contributor.authorKaaks, Ren_US
dc.contributor.authorTurzanski-Fortner, Ren_US
dc.contributor.authorAleksandrova, Ken_US
dc.contributor.authorSchulze, MBen_US
dc.contributor.authorDahm, CCen_US
dc.contributor.authorVistisen, HTen_US
dc.contributor.authorRostgaard-Hansen, ALen_US
dc.contributor.authorTjonneland, Aen_US
dc.contributor.authorBonet, Cen_US
dc.contributor.authorSánchez García, María Joséen_US
dc.contributor.authorColorado-Yohar, Sen_US
dc.contributor.authorMasala, Gen_US
dc.contributor.authorPalli, Den_US
dc.contributor.authorKrogh, Ven_US
dc.contributor.authorRicceri, Fen_US
dc.contributor.authorRolandsson, Oen_US
dc.contributor.authorLu, SSMen_US
dc.contributor.authorTsilidis, KKen_US
dc.contributor.authorWeiderpass, Een_US
dc.contributor.authorGunter, MJen_US
dc.contributor.authorFerrari, Pen_US
dc.contributor.authorBerger, Uen_US
dc.contributor.authorArnold, Men_US
dc.date.accessioned2023-07-17T15:08:04Z-
dc.date.available2023-07-17T15:08:04Z-
dc.date.issued2022en_US
dc.identifier.issn1471-2407en_US
dc.identifier.urihttp://hdl.handle.net/10553/123970-
dc.description.abstractBackground: Body mass index (BMI) and cardiometabolic comorbidities such as cardiovascular disease and type 2 diabetes have been studied as negative prognostic factors in cancer survival, but possible dependencies in the mechanisms underlying these associations remain largely unexplored. We analysed these associations in colorectal and breast cancer patients. Methods: Based on repeated BMI assessments of cancer-free participants from four European countries in the European Prospective Investigation into Cancer and nutrition (EPIC) study, individual BMI-trajectories reflecting predicted mean BMI between ages 20 to 50 years were estimated using a growth curve model. Participants with incident colorectal or breast cancer after the age of 50 years were included in the survival analysis to study the prognostic effect of mean BMI and cardiometabolic diseases (CMD) prior to cancer. CMD were defined as one or more chronic conditions among stroke, myocardial infarction, and type 2 diabetes. Hazard ratios (HRs) and confidence intervals (CIs) of mean BMI and CMD were derived using multivariable-adjusted Cox proportional hazard regression for mean BMI and CMD separately and both exposures combined, in subgroups of localised and advanced disease. Results: In the total cohort of 159,045 participants, there were 1,045 and 1,620 eligible patients of colorectal and breast cancer. In colorectal cancer patients, a higher BMI (by 1 kg/m2) was associated with a 6% increase in risk of death (95% CI of HR: 1.02–1.10). The HR for CMD was 1.25 (95% CI: 0.97–1.61). The associations for both exposures were stronger in patients with localised colorectal cancer. In breast cancer patients, a higher BMI was associated with a 4% increase in risk of death (95% CI: 1.00–1.08). CMDs were associated with a 46% increase in risk of death (95% CI: 1.01–2.09). The estimates and CIs for BMI remained similar after adjustment for CMD and vice versa. Conclusions: Our results suggest that cumulative exposure to higher BMI during early to mid-adulthood was associated with poorer survival in patients with breast and colorectal cancer, independent of CMD prior to cancer diagnosis. The association between a CMD diagnosis prior to cancer and survival in patients with breast and colorectal cancer was independent of BMI.en_US
dc.languageengen_US
dc.relation.ispartofBMC Canceren_US
dc.sourceBMC Cancer [1471-2407], v. 22:546 (Mayo 2022)en_US
dc.subject32 Ciencias médicasen_US
dc.subject320713 Oncologíaen_US
dc.subject.otherBody mass indexen_US
dc.subject.otherBreast canceren_US
dc.subject.otherColorectal canceren_US
dc.subject.otherCardiovascular diseaseen_US
dc.subject.otherDiabetesen_US
dc.subject.otherComorbidityen_US
dc.subject.otherCumulative exposureen_US
dc.subject.otherSurvivalen_US
dc.subject.otherCohort studyen_US
dc.titleImpact of cumulative body mass index and cardiometabolic diseases on survival among patients with colorectal and breast cancer: a multi-centre cohort studyen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/s12885-022-09589-yen_US
dc.identifier.pmid35568802-
dc.identifier.scopus2-s2.0-85130038163-
dc.identifier.isiWOS:000796063100003-
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dc.identifier.issue1-
dc.relation.volume22en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages11en_US
dc.utils.revisionen_US
dc.date.coverdateMayo 2022en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,137
dc.description.jcr3,8
dc.description.sjrqQ1
dc.description.jcrqQ2
dc.description.scieSCIE
dc.description.miaricds10,8
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptGIR IUIBS: Diabetes y endocrinología aplicada-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IOCAG: Geología Aplicada y Regional-
crisitem.author.deptIU de Oceanografía y Cambio Global-
crisitem.author.deptDepartamento de Física-
crisitem.author.orcid0000-0001-8888-395X-
crisitem.author.orcid0000-0002-9490-9914-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Oceanografía y Cambio Global-
crisitem.author.fullNameDávila Batista, Verónica-
crisitem.author.fullNameSánchez García, María José-
Colección:Artículos
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