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Title: Longitudinal body mass index and cancer risk: a cohort study of 2.6 million Catalan adults
Authors: Recalde, Martina
Pistillo, Andrea
Dávila Batista, Verónica 
Leitzmann, Michael
Romieu, Isabelle
Viallon, Vivian
Freisling, Heinz
Duarte Salles, Talita
UNESCO Clasification: 32 Ciencias médicas
Issue Date: 2023
Journal: Nature Communications 
Abstract: Abstract Single body mass index (BMI) measurements have been associated with increased risk of 13 cancers. Whether life course adiposity-related exposures are more relevant cancer risk factors than baseline BMI (ie, at start of follow-up for disease outcome) remains unclear. We conducted a cohort study from 2009 until 2018 with population-based electronic health records in Catalonia, Spain. We included 2,645,885 individuals aged ≥40 years and free of cancer in 2009. After 9 years of follow-up, 225,396 participants were diagnosed with cancer. This study shows that longer duration, greater degree, and younger age of onset of overweight and obesity during early adulthood are positively associated with risk of 18 cancers, including leukemia, non-Hodgkin lymphoma, and among never-smokers, head and neck, and bladder cancers which are not yet considered as obesity-related cancers in the literature. Our findings support public health strategies for cancer prevention focussing on preventing and reducing early overweight and obesity.
ISSN: 2041-1723
DOI: 10.1038/s41467-023-39282-y
Source: Nature Communications, [ISSN 2041-1723], v.14, p. 1-11, (2023).
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