Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/123260
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dc.contributor.authorTena Pérez, Víctoren_US
dc.contributor.authorApaza Ticona, Luisen_US
dc.contributor.authorH. Cabanillas, Alfredoen_US
dc.contributor.authorMaderuelo Corral, Santiagoen_US
dc.contributor.authorRosero Valencia, Diego Fernandoen_US
dc.contributor.authorMartel Quintana, Anteraen_US
dc.contributor.authorOrtega Domenech, Montserraten_US
dc.contributor.authorRumbero Sánchez, Ángelen_US
dc.date.accessioned2023-06-06T07:11:57Z-
dc.date.available2023-06-06T07:11:57Z-
dc.date.issued2023en_US
dc.identifier.issn1660-3397en_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/123260-
dc.description.abstractNocuolin A (1), an oxadiazine, was isolated from the cyanobacterium Nostoc sp. Its chemical structure was elucidated using NMR and mass spectroscopic data. From this compound, two new oxadiazines, 3-[(6R)-5,6-dihydro-4,6-dipentyl-2H-1,2,3-oxadiazin-2-yl]-3-oxopropyl acetate (2) and 4-{3-[(6R)-5,6-dihydro-4,6-dipentyl-2H-1,2,3-oxadiazin-2-yl]-3-oxopropoxy}-4-oxobutanoic acid (3), were synthesised. The chemical structures of these two compounds were elucidated by a combination of NMR and MS analysis. Compound 3 showed cytotoxicity against the ACHN (0.73 ± 0.10 μM) and Hepa-1c1c7 (0.91 ± 0.08 μM) tumour cell lines. Similarly, compound 3 significantly decreased cathepsin B activity in ACHN and Hepa-1c1c7 tumour cell lines at concentrations of 1.52 ± 0.13 nM and 1.76 ± 0.24 nM, respectively. In addition, compound 3 showed no in vivo toxicity in a murine model treated with a dose of 4 mg/kg body weight.en_US
dc.languageengen_US
dc.relation.ispartofMarine Drugsen_US
dc.sourceMarine Drugs[EISSN 1660-3397],v. 21 (5), 284, (Mayo 2023)en_US
dc.subject339001 Biotecnología de microalgasen_US
dc.subject241707 Algología (ficología)en_US
dc.subject320907 Fitofármacosen_US
dc.subject.otherAnti-Tumouralen_US
dc.subject.otherCathepsinsen_US
dc.subject.otherNostocen_US
dc.subject.otherOxadiazinesen_US
dc.titleIsolation of Nocuolin A and Synthesis of New Oxadiazine Derivatives. Design, Synthesis, Molecular Docking, Apoptotic Evaluation, and Cathepsin B Inhibitionen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/md21050284en_US
dc.identifier.scopus85160363684-
dc.contributor.orcidNO DATA-
dc.contributor.orcid0000-0002-7135-3909-
dc.contributor.orcidNO DATA-
dc.contributor.orcidNO DATA-
dc.contributor.orcidNO DATA-
dc.contributor.orcid0000-0002-7450-0505-
dc.contributor.orcidNO DATA-
dc.contributor.orcidNO DATA-
dc.contributor.authorscopusid56072150900-
dc.contributor.authorscopusid55142024800-
dc.contributor.authorscopusid58290402200-
dc.contributor.authorscopusid57200920009-
dc.contributor.authorscopusid57200916252-
dc.contributor.authorscopusid57200914955-
dc.contributor.authorscopusid57200917636-
dc.contributor.authorscopusid57200916894-
dc.identifier.eissn1660-3397-
dc.identifier.issue5-
dc.relation.volume21en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.notasThis article belongs to the Special Issue Total Synthesis of Marine Natural Products and Analoguesen_US
dc.utils.revisionen_US
dc.date.coverdateMayo 2023en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-VETen_US
dc.description.sjr0,88
dc.description.jcr5,4
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
dc.description.miaricds10,8
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptGIR IOCAG: Oceanografía Biológica y Algología Aplicada-
crisitem.author.deptIU de Oceanografía y Cambio Global-
crisitem.author.orcid0000-0002-7450-0505-
crisitem.author.parentorgIU de Oceanografía y Cambio Global-
crisitem.author.fullNameMartel Quintana,Antera De Jesús-
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