Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/123260
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tena Pérez, Víctor | en_US |
dc.contributor.author | Apaza Ticona, Luis | en_US |
dc.contributor.author | H. Cabanillas, Alfredo | en_US |
dc.contributor.author | Maderuelo Corral, Santiago | en_US |
dc.contributor.author | Rosero Valencia, Diego Fernando | en_US |
dc.contributor.author | Martel Quintana, Antera | en_US |
dc.contributor.author | Ortega Domenech, Montserrat | en_US |
dc.contributor.author | Rumbero Sánchez, Ángel | en_US |
dc.date.accessioned | 2023-06-06T07:11:57Z | - |
dc.date.available | 2023-06-06T07:11:57Z | - |
dc.date.issued | 2023 | en_US |
dc.identifier.issn | 1660-3397 | en_US |
dc.identifier.other | Scopus | - |
dc.identifier.uri | http://hdl.handle.net/10553/123260 | - |
dc.description.abstract | Nocuolin A (1), an oxadiazine, was isolated from the cyanobacterium Nostoc sp. Its chemical structure was elucidated using NMR and mass spectroscopic data. From this compound, two new oxadiazines, 3-[(6R)-5,6-dihydro-4,6-dipentyl-2H-1,2,3-oxadiazin-2-yl]-3-oxopropyl acetate (2) and 4-{3-[(6R)-5,6-dihydro-4,6-dipentyl-2H-1,2,3-oxadiazin-2-yl]-3-oxopropoxy}-4-oxobutanoic acid (3), were synthesised. The chemical structures of these two compounds were elucidated by a combination of NMR and MS analysis. Compound 3 showed cytotoxicity against the ACHN (0.73 ± 0.10 μM) and Hepa-1c1c7 (0.91 ± 0.08 μM) tumour cell lines. Similarly, compound 3 significantly decreased cathepsin B activity in ACHN and Hepa-1c1c7 tumour cell lines at concentrations of 1.52 ± 0.13 nM and 1.76 ± 0.24 nM, respectively. In addition, compound 3 showed no in vivo toxicity in a murine model treated with a dose of 4 mg/kg body weight. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Marine Drugs | en_US |
dc.source | Marine Drugs[EISSN 1660-3397],v. 21 (5), 284, (Mayo 2023) | en_US |
dc.subject | 339001 Biotecnología de microalgas | en_US |
dc.subject | 241707 Algología (ficología) | en_US |
dc.subject | 320907 Fitofármacos | en_US |
dc.subject.other | Anti-Tumoural | en_US |
dc.subject.other | Cathepsins | en_US |
dc.subject.other | Nostoc | en_US |
dc.subject.other | Oxadiazines | en_US |
dc.title | Isolation of Nocuolin A and Synthesis of New Oxadiazine Derivatives. Design, Synthesis, Molecular Docking, Apoptotic Evaluation, and Cathepsin B Inhibition | en_US |
dc.type | info:eu-repo/semantics/Article | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.3390/md21050284 | en_US |
dc.identifier.scopus | 85160363684 | - |
dc.contributor.orcid | NO DATA | - |
dc.contributor.orcid | 0000-0002-7135-3909 | - |
dc.contributor.orcid | NO DATA | - |
dc.contributor.orcid | NO DATA | - |
dc.contributor.orcid | NO DATA | - |
dc.contributor.orcid | 0000-0002-7450-0505 | - |
dc.contributor.orcid | NO DATA | - |
dc.contributor.orcid | NO DATA | - |
dc.contributor.authorscopusid | 56072150900 | - |
dc.contributor.authorscopusid | 55142024800 | - |
dc.contributor.authorscopusid | 58290402200 | - |
dc.contributor.authorscopusid | 57200920009 | - |
dc.contributor.authorscopusid | 57200916252 | - |
dc.contributor.authorscopusid | 57200914955 | - |
dc.contributor.authorscopusid | 57200917636 | - |
dc.contributor.authorscopusid | 57200916894 | - |
dc.identifier.eissn | 1660-3397 | - |
dc.identifier.issue | 5 | - |
dc.relation.volume | 21 | en_US |
dc.investigacion | Ciencias de la Salud | en_US |
dc.type2 | Artículo | en_US |
dc.description.notas | This article belongs to the Special Issue Total Synthesis of Marine Natural Products and Analogues | en_US |
dc.utils.revision | Sí | en_US |
dc.date.coverdate | Mayo 2023 | en_US |
dc.identifier.ulpgc | Sí | en_US |
dc.contributor.buulpgc | BU-VET | en_US |
dc.description.sjr | 0,88 | |
dc.description.jcr | 5,4 | |
dc.description.sjrq | Q1 | |
dc.description.jcrq | Q1 | |
dc.description.scie | SCIE | |
dc.description.miaricds | 10,8 | |
item.grantfulltext | open | - |
item.fulltext | Con texto completo | - |
crisitem.author.dept | GIR IOCAG: Oceanografía Biológica y Algología Aplicada | - |
crisitem.author.dept | IU de Oceanografía y Cambio Global | - |
crisitem.author.orcid | 0000-0002-7450-0505 | - |
crisitem.author.parentorg | IU de Oceanografía y Cambio Global | - |
crisitem.author.fullName | Martel Quintana,Antera De Jesús | - |
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