Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/122026
Title: Immunization with thiol-binding proteins from Haemonchus contortus adult worms partially protects goats against infection during prepatency
Authors: Molina Caballero, José Manuel 
Hernández Ortega,Yeray 
Ferrer Quintana, Otilia Rosa 
Conde-Felipe, Magnolia M. 
Rodríguez Guisado, Francisco 
Ruiz Reyes, Antonio 
UNESCO Clasification: 3104 Producción Animal
310905 Microbiología
310903 Inmunología
Keywords: Goat
Haemonchus contortus
Immune response
Prepatency
Thiol-binding proteins, et al
Issue Date: 2023
Journal: Experimental parasitology 
Abstract: To contribute of the knowledge of the immune mechanisms underlying the response to the immunization of goats with thiol-binding proteins fractions (PBS-TSBP) from Haemonchus contortus (H. contortus) adult worms, this study analyzed the degree of protection and the immune responses developed against the parasite after vaccination with this antigenic complex during the time-elapsing between challenge with L3 of the parasite and the development of adult worms, evidenced by the appearance of first faecal eggs (prepatent period or prepatency). Goat kids immunized with PBS-TBSP generated an immune response during the prepatency which translates into a reduction in the number of worms, as well as a lower reduction on packed cell volume and plasma protein levels in relation to the non-vaccinated animals. As previously described in other studies carried out after the prepatent period, this protection was associated with a systemic humoral response. At the local level, a specific humoral response was also observed, together with an immune-inflammatory infiltrate in the gastric mucosa of MCH-II + cells and CD4+ lymphocytes, whose number was associated with a reduction in the number of worms and an increase in plasma proteins. A high peripheral eosinophilia was detected, but no corresponding increased infiltration of the gastric mucosa by eosinophils or globular leukocytes was observed. In agreement with previous data on the immunolocalization of the antigens used here, the results obtained contribute to the idea that these may be excretion/secretion (E/S) products necessary for parasite survival, whose inactivation during the larval and/or pre-adult stages may have contributed to immunoprotection.
URI: http://hdl.handle.net/10553/122026
ISSN: 0014-4894
DOI: 10.1016/j.exppara.2023.108512
Source: Experimental parasitology [ISSN 0014-4894], v. 248, 108512, (Mayo 2023)
Appears in Collections:Artículos
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