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Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/122001
DC FieldValueLanguage
dc.contributor.authorMuñoz Descalzo, Silviaen_US
dc.contributor.authorSanders, Phil G. T.en_US
dc.contributor.authorMontagne, Chrystelleen_US
dc.contributor.authorJohnson, Ruth I.en_US
dc.contributor.authorBalayo, Tinaen_US
dc.contributor.authorMartínez Arias, Alfonsoen_US
dc.date.accessioned2018-11-25T20:19:09Z-
dc.date.accessioned2023-04-24T13:04:22Z-
dc.date.available2018-11-25T20:19:09Z-
dc.date.available2023-04-24T13:04:22Z-
dc.date.issued2010en_US
dc.identifier.issn1933-6934en_US
dc.identifier.urihttp://hdl.handle.net/10553/122001-
dc.description.abstractHere we investigate the structural and functional basis of the interactions between Notch and Wingless signalling in Drosophila. Using yeast-two-hybrid and pull-down assays we show that Notch can bind directly a form of Dishevelled that is stabilized upon Wingless signalling. Moreover, we show that the mechanism by which Wingless signalling is able to downregulate Notch is by promoting its ligand-independent traffic to a compartment where it is degraded and that this activity depends on Dishevelled.en_US
dc.languageengen_US
dc.relation.ispartofFlyen_US
dc.sourceFly [ISSN 1933-6934], v. 4 (3), p. 182-193, (2010)en_US
dc.subject32 Ciencias médicasen_US
dc.subject320102 Genética clínicaen_US
dc.subject.otherCrosstalken_US
dc.subject.otherNotchen_US
dc.subject.otherSignallingen_US
dc.subject.otherTrafficen_US
dc.subject.otherWinglessen_US
dc.titleWingless modulates the ligand independent traffic of Notch through Dishevelleden_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.4161/fly.4.3.11998en_US
dc.identifier.pmid20495361-
dc.identifier.scopus2-s2.0-77957730430-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.contributor.authorscopusid9235908900-
dc.contributor.authorscopusid56596190900-
dc.contributor.authorscopusid36898840000-
dc.contributor.authorscopusid23990747700-
dc.contributor.authorscopusid8406257400-
dc.contributor.authorscopusid57204246803-
dc.description.lastpage193en_US
dc.identifier.issue3-
dc.description.firstpage182en_US
dc.relation.volume4en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.external62311699-
dc.description.numberofpages12en_US
dc.utils.revisionSíen_US
dc.identifier.ulpgcNoen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr1,468-
dc.description.jcrqQ4-
dc.description.scieSCIE-
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Diabetes y endocrinología aplicada-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.orcid0000-0003-0939-7721-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameMuñoz Descalzo, Silvia-
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