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Title: Variability in the Response against Teladorsagia circumcincta in Lambs of Two Canarian Sheep Breeds
Authors: Pérez Hernández, Tara 
Hernández Vega, Julia Natividad 
Machín, Cynthia 
McNeilly, Tom N.
Nisbet, Alasdair J.
Matthews, Jacqueline B.
Burgess, Stewart T. G.
González, Jorge F. 
UNESCO Clasification: 310907 Patología
3104 Producción Animal
Keywords: Gastrointestinal nematodes
Genetic resistance
Transcriptomic analysis
Issue Date: 2023
Project: PARAGONE: vaccines for animal parasites 
Journal: International Journal of Molecular Sciences 
Abstract: The increasing resistance to anthelmintics has necessitated the exploration of alternative control strategies of gastrointestinal nematode (GIN) infections. A sustainable option is genetic selection based on differences in susceptibility to GIN infection between and within breeds of sheep. Here, three-month-old Canaria Hair breed (GIN-resistant) and Canaria Sheep breed (GIN-susceptible) showed no significant between-breed differences after trickle infection with Teladorsagia circumcincta, whereas considerable individual variability was found in both breeds. Next, data from lambs of both breeds were used to explore the relationships between parasitological variables and T. circumcincta-specific IgA levels, local immune cell populations, and abomasal lymph node gene expression to understand the possible mechanisms underlying resistance. Mucosal IgA levels as well as numbers of globular leukocytes and MHC-II+ cells were associated with protection. Analysis of lymph node gene expression revealed the associations between lower parasite numbers and cumulative fecal egg counts and several immune pathways, such as leukocyte cell adhesion, activation and differentiation of T cells, in particular CD4+ and IL-4 production. The data obtained here may inform on the relationship between phenotypic resistance variability and protective responses at the humoral, cellular, and transcriptomic levels, thus contributing to identifying immune responses in young lambs that could be used as markers for selection.
ISSN: 1661-6596
DOI: 10.3390/ijms24010029
Source: International Journal of Molecular Sciences [ISSN 1661-6596], v. 23 (1), 29, (Diciembre 2022)
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