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http://hdl.handle.net/10553/121187
Title: | Structural and Mechanical Properties of TTR105-115 Amyloid Fibrils from Compression Experiments | Authors: | Meersman, Filip Quesada Cabrera, Raúl McMillan, Paul F. Dmitriev, Vladimir |
UNESCO Clasification: | 221104 Cristalografía 230418 Polipéptidos y proteínas 221119 Propiedades mecánicas |
Issue Date: | 2011 | Journal: | Biophysical journal (Print) | Abstract: | Amyloid fibrils, originally associated with neurodegenerative diseases, are now recognized to have interesting mechanical properties. By using synchrotron x-ray diffraction at high pressure in a diamond anvil cell we determined the bulk modulus of TTR105-115 amyloid fibrils in water and in silicone oil to be 2.6 and 8.1 GPa, respectively. The compression characteristics of the fibrils are quite different in the two media, revealing the presence of cavities along the axis of the fibrils, but not between the β-sheets, which are separated by a dry interface as in a steric zipper motif. Our results emphasize the importance of peptide packing in determining the structural and mechanical properties of amyloid fibrils. | URI: | http://hdl.handle.net/10553/121187 | ISSN: | 0006-3495 | DOI: | 10.1016/j.bpj.2010.11.052 | Source: | Biophysical journal [ISSN 0006-3495], v. 100(1), p. 193-197 |
Appears in Collections: | Artículos |
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