Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/121187
Title: Structural and Mechanical Properties of TTR105-115 Amyloid Fibrils from Compression Experiments
Authors: Meersman, Filip
Quesada Cabrera, Raúl 
McMillan, Paul F.
Dmitriev, Vladimir
UNESCO Clasification: 221104 Cristalografía
230418 Polipéptidos y proteínas
221119 Propiedades mecánicas
Issue Date: 2011
Journal: Biophysical journal (Print) 
Abstract: Amyloid fibrils, originally associated with neurodegenerative diseases, are now recognized to have interesting mechanical properties. By using synchrotron x-ray diffraction at high pressure in a diamond anvil cell we determined the bulk modulus of TTR105-115 amyloid fibrils in water and in silicone oil to be 2.6 and 8.1 GPa, respectively. The compression characteristics of the fibrils are quite different in the two media, revealing the presence of cavities along the axis of the fibrils, but not between the β-sheets, which are separated by a dry interface as in a steric zipper motif. Our results emphasize the importance of peptide packing in determining the structural and mechanical properties of amyloid fibrils.
URI: http://hdl.handle.net/10553/121187
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2010.11.052
Source: Biophysical journal [ISSN 0006-3495], v. 100(1), p. 193-197
Appears in Collections:Artículos
Adobe PDF (517,88 kB)
Show full item record

SCOPUSTM   
Citations

20
checked on Nov 3, 2024

WEB OF SCIENCETM
Citations

20
checked on Nov 3, 2024

Page view(s)

9
checked on Dec 16, 2023

Download(s)

5
checked on Dec 16, 2023

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.