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Title: NOS3 RS1799983 and RS2070744 Polymorphisms and their Association with Advanced Chronic Kidney Disease and Coronary Heart Disease in Canarian Population with Type 2 Diabetes
Authors: Boronat Cortés, Mauro 
Tugores Céster,Antonio 
Saavedra Santana, Pedro 
Garay, P
Bosch, E
Lorenzo, D
Ibarra, A
García Cantón, César 
UNESCO Clasification: 32 Ciencias médicas
320502 Endocrinología
Keywords: NOS3
Endothelial nitric oxide synthase
Type 2 diabetes
Chronic kidney disease
Diabetic nephropathy, et al
Issue Date: 2021
Journal: Acta Endocrinologica 
Abstract: Context. Different polymorphisms of the endothelial nitric oxide synthase gene (NOS3) have been related to diabetic kidney disease. Objective. To evaluate the association between advanced diabetic chronic kidney disease (ACKD) and the rs1799983 and rs2070744 poymorphisms of NOS3 in a population from the Gran Canaria island. Design. Cross-sectional case-control study. Subjects and methods. Polymorphisms were genotyped in 152 subjects with ACKD secondary to type 2 diabetes [estimated glomerular filtration rate (eGFR) <30 mL/min/1.73 m2], 110 subjects with type 2 diabetes for 20 or more years since diagnosis without ACKD (eGFR ≥45 mL/ min/1.73m2 and albumin/creatinine ratio <300 mg/g and/or 24-h urinary albumin excretion <300 mg) and 292 healthy controls. Association between both polymorphisms and established coronary heart disease (CHD) was also analyzed in both groups with diabetes. Results. A greater proportion of homozygous individuals for the risk allele C of rs2070744 was found among subjects with ACKD. Association between ACKD and rs2070744 was observed in a recessive genetic model, both for comparison to subjects with diabetes but no ACKD [OR 2.17 (95% CI: 1.17-4.00), p=0.014] and for comparison to healthy controls [OR 1.61 (1.03-2.52), p=0.036]. The frequency of the C allele was significantly higher among subjects with CHD, but only in the group with ACKD. No associations were found for rs1799983. Conclusions. NOS3 rs2070744 is associated with ACKD in population with type 2 diabetes from Gran Canaria. A link between this genetic variant and CHD in Canarian subjects with type 2 diabetes could be restricted to cases with ACKD.
ISSN: 1841-0987
DOI: 10.4183/aeb.2021.440
Source: Acta Endocrinologica [ISSN 1841-0987], v. 17 (4), p. 440-448, (Octubre-Diciembre 2021)
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