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Title: Short-term evaluation of renal markers in overweight adult cats
Authors: Pérez López, Laura Del Carmen 
Boronat Cortés, Mauro 
Melián Limiñana, Carlos 
Santana Del Pino, Ángelo 
Brito Casillas, Yeray 
Wägner, Anna Maria Claudia 
UNESCO Clasification: 310904 Medicina interna
Keywords: Chronic Kidney Disease
Symmetric Dimethylarginine
Issue Date: 2023
Journal: Veterinary Medicine and Science 
Abstract: Veterinary Medicine and Science published by John Wiley & Sons Ltd.Background: Obesity has been proposed as an independently risk factor for chronic kidney disease (CKD) in people, but its role in feline kidney function is unknown. Objective: Obesity has been proposed as an independent risk factor for chronic kidney disease (CKD) in people, but its role in feline kidney function is unknown. This study prospectively evaluated the effect of overweight on the concentration of symmetric dimethylarginine (SDMA) and creatinine in a cohort of healthy cats. Methods: Forty healthy adult cats were included, 14 with a body condition score (BCS) = 5 and 26 with a BCS > 5. Cats were examined every 6 months, for up to 12 months. SDMA and creatinine were measured at baseline and follow-up. Results: No effect was found for time of follow-up (p = 0.072), overweight (p = 0.9442) or their interaction (p = 0.902) on SDMA, though a significant effect was found for age (p < 0.001) [older cats showing higher SDMA] and sex (p = 0.007) [male cats showing higher SDMA]. Regarding creatinine, no effect for time (p = 0.671), age (p = 0.061), overweight (p = 0.319) or the latter's interaction (p = 0.386) were found. Conclusions: In the short term, markers of renal function did not show an association with overweight. The role of obesity in feline kidney function still warrants further evaluation.
ISSN: 2053-1095
DOI: 10.1002/vms3.1021
Source: Veterinary Medicine and Science [EISSN 2053-1095], (Enero 2023)
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