Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/119984
Title: Modification of Antibiotic Activity by Fixed Oil of the Artocarpus heterophyllus Almond against Standard and Multidrug-Resistant Bacteria Strains
Authors: Dias, Cícera Janayne Ferreira
Raposo, António
de Sousa, Cícera Dayane Thais
de Araújo-Neto, José Bezerra
Tintino, Saulo Relison
Oliveira-Tintino, Cícera Datiane de Morais
Araújo, Isaac Moura
Coutinho, Henrique Douglas Melo
Costa, Mayra Garcia Maia
Lima, Cleidiane Gomes
de Alencar, Mairlane Silva
Carrascosa Iruzubieta, Conrado Javier 
De Figueiredo Saraiva, Ariana Maria 
de Sousa, Erlânio Oliveira
UNESCO Clasification: 241401 Antibióticos
330990 Microbiología de alimentos
Keywords: Antibacterial
Antibiotic Resistance
Fatty Acid
Jackfruit
Issue Date: 2022
Journal: Biology 
Abstract: Artocarpus heterophyllus (jackfruit) is an evergreen tree distributed in tropical regions and is among the most studied species of the genus Artocarpus. The jackfruit almond has been highlighted in relation to phytochemical studies, biological properties, and application in the development of food products. This study aimed to analyze jackfruit fixed oil regarding chemical components, antibacterial property alone, and in association with antibiotics against standard and MDR bacteria strains. In the analysis of the oil by gas chromatography coupled to a flame ionization detector (GC-FID), a high content of saturated fatty acids (78.51%) was identified in relation to unsaturated fatty acids (17.07%). The main fatty acids identified were lauric acid (43.01%), myristic acid (11.10%), palmitic acid (6.95%), and oleic acid (15.32%). In the antibacterial analysis, broth microdilution assays were used. The oil presented minimum inhibitory concentration (MIC) ≥ 1024 μg/mL in antibacterial analysis for standard and MDR bacterial strains. The oil showed synergistic effects in the association with gentamicin, ofloxacin, and penicillin against MDR strains, with significant reductions in the MIC of antibiotics. The results suggest that the fixed oil of A. heterophyllus has fatty acids with the potential to synergistically modify antibiotic activity.
URI: http://hdl.handle.net/10553/119984
ISSN: 2079-7737
DOI: 10.3390/biology11121835
Source: Biology [EISSN 2079-7737], v. 11 (12), 1835, (Diciembre 2022)
Appears in Collections:Artículos
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