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http://hdl.handle.net/10553/119984
Title: | Modification of Antibiotic Activity by Fixed Oil of the Artocarpus heterophyllus Almond against Standard and Multidrug-Resistant Bacteria Strains | Authors: | Dias, Cícera Janayne Ferreira Raposo, António de Sousa, Cícera Dayane Thais de Araújo-Neto, José Bezerra Tintino, Saulo Relison Oliveira-Tintino, Cícera Datiane de Morais Araújo, Isaac Moura Coutinho, Henrique Douglas Melo Costa, Mayra Garcia Maia Lima, Cleidiane Gomes de Alencar, Mairlane Silva Carrascosa Iruzubieta, Conrado Javier De Figueiredo Saraiva, Ariana Maria de Sousa, Erlânio Oliveira |
UNESCO Clasification: | 241401 Antibióticos 330990 Microbiología de alimentos |
Keywords: | Antibacterial Antibiotic Resistance Fatty Acid Jackfruit |
Issue Date: | 2022 | Journal: | Biology | Abstract: | Artocarpus heterophyllus (jackfruit) is an evergreen tree distributed in tropical regions and is among the most studied species of the genus Artocarpus. The jackfruit almond has been highlighted in relation to phytochemical studies, biological properties, and application in the development of food products. This study aimed to analyze jackfruit fixed oil regarding chemical components, antibacterial property alone, and in association with antibiotics against standard and MDR bacteria strains. In the analysis of the oil by gas chromatography coupled to a flame ionization detector (GC-FID), a high content of saturated fatty acids (78.51%) was identified in relation to unsaturated fatty acids (17.07%). The main fatty acids identified were lauric acid (43.01%), myristic acid (11.10%), palmitic acid (6.95%), and oleic acid (15.32%). In the antibacterial analysis, broth microdilution assays were used. The oil presented minimum inhibitory concentration (MIC) ≥ 1024 μg/mL in antibacterial analysis for standard and MDR bacterial strains. The oil showed synergistic effects in the association with gentamicin, ofloxacin, and penicillin against MDR strains, with significant reductions in the MIC of antibiotics. The results suggest that the fixed oil of A. heterophyllus has fatty acids with the potential to synergistically modify antibiotic activity. | URI: | http://hdl.handle.net/10553/119984 | ISSN: | 2079-7737 | DOI: | 10.3390/biology11121835 | Source: | Biology [EISSN 2079-7737], v. 11 (12), 1835, (Diciembre 2022) |
Appears in Collections: | Artículos |
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