Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/119461
Título: Randomized trial comparing albumin, dextran 70, and polygeline in cirrhotic patients with ascites treated by paracentesis8831595
Autores/as: Ginés, A.
Fernández Esparrach, G.
Monescillo Francia, Alberto Fernando 
Vila, C.
Domenech, E.
Abecasis, R.
Angeli, P.
Ruiz del Árbol, L.
Planas, R.
Sola, R.
Ginés, P.
Terg, R.
Inglada, L.
Vaque, P.
Salerno, F.
Vargas, V.
Clemente, G.
Quer, J.C.
Jiménez, W.
Arroyo, V.
Rodes, J.
Clasificación UNESCO: 32 Ciencias médicas
320503 Gastroenterología
Palabras clave: Albumin
Dextran 70
Cirrhosis
Ascites
Paracentesis
Fecha de publicación: 1996
Publicación seriada: Gastroenterology 
Resumen: BACKGROUND & AIMS: Paracentesis associated with plasma expanders is widely used for the treatment of ascites in cirrhosis. This study investigated the clinical importance of paracentesis-induced- circulatory dysfunction and compared the efficacy of albumin, dextran 70, and polygeline in preventing this complication. METHODS: A total of 289 cirrhotic patients with ascites were randomized to treatment by total paracentesis plus intravenous albumin (97 patients), dextran 70 (93 patients), or polygeline (99 patients). Postparacentesis circulatory dysfunction was defined as an increase in plasma renin activity on the sixth day after paracentesis of more than 50% of the pretreatment value to a level > 4 ng.mL-1.h-1. RESULTS: Postparacentesis circulatory dysfunction occurred more frequently in patients treated with dextran 70 (34.4%; P = 0.018) or polygeline (37.8%; P = 0.004) than in those receiving albumin (18.5%). The plasma expander used and the volume of ascites removed were independent predictors of this complication. Postparacentesis circulatory dysfunction persisted during follow-up and was associated with a shorter time to first readmission (1.3 +/- 0.5 vs. 3.5 +/- 0.8 months, median +/- SEM; P = 0.03) and shorter survival (9.3 +/- 4.2 vs. 16.9 +/- 4.3 months; P = 0.01). Creatinine and sodium levels in serum, and Child- Pugh score at inclusion, and postparacentesis circulatory dysfunction were independent predictors of survival. CONCLUSIONS: Postparacentesis circulatory dysfunction is not spontaneously reversible and is associated with a shorter time to first readmission and shorter survival. Albumin is the best plasma expander to prevent this complication.
URI: http://hdl.handle.net/10553/119461
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(96)70068-9
Fuente: Gastroenterology [0016-5085], v. 111(4), pp. 1002-1010
Colección:Artículos
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