Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/119444
Título: Mechanisms of Actions Involved in The Antinociceptive Effect of Estragole and its β-Cyclodextrin Inclusion Complex in Animal Models
Autores/as: da Costa, Roger Henrique Sousa
Martins, Anita Oliveira Brito Pereira Bezerra
Pessoa, Renata Torres
Alshehri, Saad Ali
Wahab, Shadma
Ahmad, Md Faruque
Suliman, Muath
da Silva, Lucas Yure Santos
Alcântara, Isabel Sousa
Ramos, Andreza Guedes Barbosa
Oliveira, Maria Rayane Correia de
Batista, Francisco Lucas Alves
Delmondes, Gyllyandeson de Araújo
de Farias, Pablo Antonio Maia
Rocha, Janaína Esmeraldo
Coutinho, Henrique Douglas Melo
Raposo, António
Carrascosa Iruzubieta, Conrado Javier 
Jáber Mohamad, José Raduán 
de Menezes, Irwin Rose Alencar
Clasificación UNESCO: 32 Ciencias médicas
3209 Farmacología
Palabras clave: Cyclodextrins
Estragole
Monoterpene
Nociception
Fecha de publicación: 2022
Publicación seriada: Plants 
Resumen: Background: estragole is a monoterpene found in the essential oils of several aromatic plants, which can be used for several pharmacological activities. The aim of this study was to evaluate the antinociceptive effect of estragole (Es) and its β-cyclodextrins inclusion complex (Es/β-CD). (2) Methods: the effects of Es and Es/β-CD on the central nervous system (CNS) were evaluated through open field and rota-rod assays, and the antinociceptive effect in formalin models, abdominal writhing induced by acetic acid, hot plate, tail flick test and plantar mechanical hyperalgesia. (3) Results: Es and Es/β-CD showed no alterations on the CNS evaluated parameters and the results suggested there was an antinociceptive action in the formalin, abdominal writhing, hot plate, tail flick tests and plantar mechanical hyperalgesia, proposing the involvement of the nitric oxide, glutamatergic signaling pathways, cyclic guanosine monophosphate and vanilloid pathways. (4) Conclusion: the results suggest that Es and Es/β-CD have a promising antinociceptive potential as a possible alternative for the pharmacological treatment of pain, also showing that the encapsulation of Es in β-cyclodextrins probably improves its pharmacological properties, since the complexation process involves much lower amounts of the compound, contributing to better bioavailability and a lower probability of adverse effect development.
URI: http://hdl.handle.net/10553/119444
ISSN: 2223-7747
DOI: 10.3390/plants11212854
Fuente: Plants [EISSN 2223-7747], v. 11 (21), 2854, (Noviembre 2022)
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