Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/119076
Título: Validated analytical methodology for the simultaneous determination of a wide range of pesticides in human blood using GC-MS/MS and LC-ESI/MS/MS and its application in two poisoning cases
Autores/as: Pérez Luzardo, Octavio Luis 
Almeida González, Maira Del Pino 
Ruiz-Suárez, N.
Zumbado Peña, Manuel Luis 
Henríquez Hernández, Luis Alberto 
Meilán, María José
Camacho Rodríguez, María De Los Ángeles 
Domínguez Boada, Luis María 
Clasificación UNESCO: 32 Ciencias médicas
Palabras clave: Forensic science
Forensic toxicology
GC-MS/MS
LC-MS/MS
Multiresidue, et al.
Fecha de publicación: 2015
Publicación seriada: Science and Justice - Journal of the Forensic Science Society 
Resumen: Pesticides are frequently responsible for human poisoning and often the information on the involved substance is lacking. The great variety of pesticides that could be responsible for intoxication makes necessary the development of powerful and versatile analytical methodologies, which allows the identification of the unknown toxic substance. Here we developed a methodology for simultaneous identification and quantification in human blood of 109 highly toxic pesticides. The application of this analytical scheme would help in minimizing the cost of this type of chemical identification, maximizing the chances of identifying the pesticide involved. In the methodology that we present here, we use a liquid-liquid extraction, followed by one single purification step, and quantitation of analytes by a combination of liquid and gas chromatography, both coupled to triple quadrupole mass spectrometry, which is operated in the mode of multiple reaction monitoring. The methodology has been fully validated, and its applicability has been demonstrated in two recent cases involving one self-poisoning fatality and one non-fatal homicidal attempt.
URI: http://hdl.handle.net/10553/119076
ISSN: 1355-0306
DOI: 10.1016/j.scijus.2015.04.007
Fuente: Science & Justice. September [1355-0306] , v. 55 (5), p.307-315 , 2015
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