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Title: Nematode galectin binds IgE and modulates mast cell activity
Authors: Donskow-Łysoniewska, Katarzyna
Maruszewska-Cheruiyot, Marta
Krawczak-Wójcik, Katarzyna
Stear, Michael 
González Pérez, Jorge Francisco 
Hernández Vega, Julia Natividad 
UNESCO Clasification: 310907 Patología
Keywords: Degranulation
Host-Parasite Interaction
Mast Cell, et al
Issue Date: 2022
Journal: Veterinary Parasitology
Abstract: Mast cell degranulation is the major mechanism influencing establishment and survival of the abomasal nematode Teladorsagia circumcincta and probably many other gastrointestinal nematodes. Host galectins-3 and -9 have been shown to bind IgE and positively and negatively influence mast cell degranulation. As incoming nematodes produce large amounts of galectin, we hypothesised that nematode galectin competes with host galectin and inhibits mast cell degranulation. ELISA was used to show that nematode galectin reduced total IgE activity. Galectin also reduced the binding of sheep IgE to the surface of a mast cell line and decreased the release of LCT-4 and Beta hexosaminidase but not MMP-9. These results indicate that nematode galectin influences mast cell degranulation and identify a potential immunomodulatory mechanism used by nematodes to enhance their establishment and survival.
ISSN: 0304-4017
DOI: 10.1016/j.vetpar.2022.109807
Source: Veterinary Parasitology [ISSN 0304-4017], v. 311, (Noviembre 2022)
Appears in Collections:Artículos
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