Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/116103
Title: Increasing incidence of pediatric inflammatory bowel disease in Spain (1996-2009): the SPIRIT Registry
Authors: Martín de Carpi, Javier
Rodríguez, Alejandro
Ramos, Esther
Jiménez, Santiago
Martínez Gómez, María José
Medina, Enrique
Peña Quintana, Luis 
UNESCO Clasification: 32 Ciencias médicas
320110 Pediatría
Keywords: Bowel
Inflammation
Spirit registry
Issue Date: 2013
Journal: Inflammatory Bowel Diseases 
Abstract: Background: Although pediatric inflammatory bowel disease (IBD) diagnosis has increased in the last decades in Spain, there are no consistent epidemiologic data. Our aim was to describe the changing pattern of pediatric IBD incidence in Spain in the last 14 years. Methods: A retrospective survey of patients diagnosed below 18 years of age in the period 1996-2009 was performed. Patients' data were obtained from the hospitals' databases. To avoid reduced accrual of cases diagnosed by adult physicians, adult IBD units in referral centers were invited to participate. Seventy-eight centers participated in our survey. Rates of incidence were calculated using age-stratified population-based epidemiologic data. Incidence rates were compared for the last 14 years (1996-2009). Results: In total, data from 2107 patients were obtained: 1,165 Crohn's disease (CD, 55.3%), 788 ulcerative colitis (UC, 37.4%), and 154 IBD unclassified. The sex distribution was 56.4% male, with higher predominance for CD (59.3%) as compared to UC (52.8%) and IBD unclassified (53.2%) (P = 0.012). The median age at diagnosis was 12.3 years (p25-75 9.7-14.6) with significant differences between diseases. IBD incidence increased from 0.97 to 2.8/100,000 inhabitants <18 years/year in the study period. Although this increase is more evident for CD (from 0.53 to 1.7), UC has also risen considerably (0.39 to 0.88). Conclusions: This is the first attempt to calculate the current incidence of pediatric IBD in Spain. A significant increase of incidence rates in the study period was observed. In the last 14 years pediatric IBD incidence has almost tripled, with a more important CD increase.
URI: http://hdl.handle.net/10553/116103
ISSN: 1078-0998
DOI: 10.1002/ibd.22980
Source: Inflammatory Bowel Disease[1078-0998], v. 19(1), pp.73-80, (Enero 2013)
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