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http://hdl.handle.net/10553/115559
Title: | Dynamics of Reverse Transcription-Polymerase Chain Reaction and Serologic Test Results in Children with SARS-CoV-2 Infection | Authors: | Tagarro, Alfredo Sanz-Santaeufemia, Francisco José Grasa, Carlos Cobos, Elena Yebra, Julia Alonso-Cadenas, Jose Antonio Baquero-Artigao, Fernando Mesa-Guzmán, Juan Miguel Pérez-Seoane, Beatriz Calvo, Cristina Herreros, María Luisa Epalza, Cristina Melendo, Susana Dominguez-Rodriguez, Sara Vidal, Paula Pacheco, Mónica Ballesteros, Alvaro Bernardino, María Villanueva-Medina, Sara Rodríguez-Molino, Paula Miragaya Castro, Sandra Rivière, Jacques Garcés, Rosa Santiago, Begoña Fumadó, Victoria Urretavizcaya-Martínez, María García-García, María Luz Penín, María Cava, Fernando Sáez, Elena Iglesias-Bouzas, María Isabel Herrero, Blanca de Jesús Reinoso, Teresa Moraleda, Cinta Peña Quintana, Luis |
UNESCO Clasification: | 32 Ciencias médicas 320110 Pediatría 320505 Enfermedades infecciosas |
Keywords: | COVID-19 SARS-CoV-2 Children Serology RT-PCR, et al |
Issue Date: | 2022 | Journal: | Journal of Pediatrics | Abstract: | Objectives To determine the time to reverse transcription-polymerase chain reaction (RT-PCR) negativity after the first positive RT-PCR test, factors associated with longer time to RT-PCR negativity, proportion of children seroconverting after proven severe acute respiratory syndrome coronavirus 2 infection, and factors associated with the lack of seroconversion. Study design The Epidemiological Study of Coronavirus in Children of the Spanish Society of Pediatrics is a multicenter study conducted in Spanish children to assess the characteristics of coronavirus disease 2019. In a subset of patients, 3 serial RT-PCR tests on nasopharyngeal swab specimens were performed after the first RT-PCR test, and immunoglobulin G serology for severe acute respiratory syndrome coronavirus 2 antibodies was performed in the acute and follow-up (<14 and ≥14 days after diagnosis) phase. Results In total, 324 patients were included in the study. The median time to RT-PCR negativity was 17 days (IQR, 8-29 days), and 35% of patients remained positive more than 4 weeks after the first RT-PCR test. The probability of RT-PCR negativity did not differ across groups defined by sex, disease severity, immunosuppressive drugs, or clinical phenotype. Globally, 24% of children failed to seroconvert after infection. Seroconversion was associated with hospitalization, persistence of RT-PCR positivity, and days of fever. Conclusions Time to RT-PCR negativity was long, regardless of the severity of symptoms or other patient features. This finding should be considered when interpreting RT-PCR results in a child with symptoms, especially those with mild symptoms. Seroprevalence and postimmunization studies should consider that 11 in 4 infected children fail to seroconvert. | URI: | http://hdl.handle.net/10553/115559 | ISSN: | 0022-3476 | DOI: | 10.1016/j.jpeds.2021.09.029 | Source: | Journal of Pediatrics [ISSN 0022-3476], v. 241, p. 126-132.e3 (Febrero 2022) |
Appears in Collections: | Artículos |
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