Please use this identifier to cite or link to this item:
Title: Molecular Characterization of Herpesviral Encephalitis in Cetaceans: Correlation with Histopathological and Immunohistochemical Findings
Authors: Sierra Pulpillo, Eva María 
Fernández Rodríguez, Antonio Jesús 
Fernández-Maldonado, Carolina
Sacchini, Simona 
Felipe Jiménez, Idaira Del Carmen 
Segura-Göthlin, Simone
Colom Rivero, Ana 
Camara, Nakita 
Puig Lozano, Raquel Patricia 
Rambaldi, Anna Maria 
Suarez Santana, Cristian Manuel 
Arbelo Hernández, Manuel Antonio 
UNESCO Clasification: 3109 Ciencias veterinarias
Keywords: Alphaherpesvirus
Intranuclear Inclusion Bodies, et al
Issue Date: 2022
Journal: Animals 
Abstract: Herpesviruses are causative agents of meningitis and encephalitis in cetaceans, which are among the main leading known natural causes of death in these species. Brain samples from 103 stranded cetaceans were retrospectively screened for the presence of herpesvirus DNA in the brain. Molecular detection of Cetacean Morbillivirus was performed in HV positive brain cases. Histo-pathologic evaluation of brain samples included the presence or absence of the following findings (n = 7): meningitis, perivascular cuffings, microgliosis, intranuclear inclusion bodies, malacia, neu-ronal necrosis and neurophagic nodules, and haemorrhages. Histological evidence of the involvement of other etiological agents led to complementary analysis. We detected the presence of alpha and gamma-HVs in 12 out of 103 (11.6%) brain samples from stranded cetaceans of five different species: one bottlenose dolphin, six striped dolphins, three Atlantic spotted dolphins, one Cuvier’s beaked whale, and one common dolphin. Pathogenic factors such as viral strain, age, sex, and the presence of co-infections were analysed and correlated with the brain histopathological findings in each case. Herpesvirus was more prevalent in males, juveniles, and calves and a 41.6% incidence of co-infections in the brain was detected in our study: three with Dolphin Morbillivirus, one with Staphilococcus aureus septicaemia and one with Brucella spp.
ISSN: 2076-2615
DOI: 10.3390/ani12091149
Source: Animals[EISSN 2076-2615],v. 12 (9), (Mayo 2022)
Appears in Collections:Artículos
Adobe PDF (3,34 MB)
Show full item record

Google ScholarTM




Export metadata

Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.