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Title: Immunoprotection against mixed Eimeria spp. infections in goat kids induced by X-irradiated oocysts
Authors: Barba, Emilio
Guedes Santana, Aranzazu Del Carmen 
Molina Caballero, José Manuel 
Martín Martel, Sergio 
Muñoz Ojeda, María Del Carmen 
Ferrer Quintana, Otilia Rosa 
Lara, Pedro Carlos
Hermosilla, Carlos
Taubert, Anja
Ruiz Reyes, Antonio 
UNESCO Clasification: 240112 Parasitología animal
310904 Medicina interna
Keywords: Eimeria Spp
X-Rad Attenuation
Issue Date: 2022
Project: Ensayos de Vacunación Frente A Coccidiosis Caprina Mediante El Empleo de Coquistes Atenuados Por Irradiación. 
Journal: Parasitology Research 
Abstract: Strategies to control goat coccidiosis traditionally rely on the use of management practices combined with anticoccidial treatments, and limited effort has been made, so far, to address immunological control of caprine Eimeria infections. Previously, we showed that monospecific immunization with X-Rad-attenuated Eimeria ninakohlyakimovae oocysts induced considerable immunoprotection upon challenge. In the present study, we conducted a similar vaccination trial but using a mixture of caprine Eimeria species typically present in natural infected goats. For immunization, sporulated oocysts were attenuated by X irradiation (20 kilorad). All infections were performed orally applying 105 sporulated oocysts of mixed Eimeria spp. per animal. In total, 18 goat kids were grouped as follows: (G1) immunized + challenge infected; (G2) primary + challenge infected; (G3) challenge infection control; and (G4) non-immunized/non-infected control. Overall, goat kids infected with attenuated oocysts (= immunized) shed less oocysts in the faeces and showed a lower degree of clinical coccidiosis than animals infected with non-attenuated oocysts. Animals of both challenge groups (G1 and G2) showed partial immunoprotection upon reinfection when compared to challenge infection control (G3). However, the degree of immunoprotection was less pronounced than recently reported for monospecific vaccination against Eimeria ninakohlyakimovae, most probably due to the complexity of the pathogenesis and related immune responses against mixed Eimeria spp. infections. Nevertheless, the data of the present study demonstrate that immunization with attenuated Eimeria spp. oocysts may be worth pursuing as a strategy to control goat coccidiosis.
ISSN: 0932-0113
DOI: 10.1007/s00436-022-07465-z
Source: Parasitology Research [ISSN 0932-0113], n. 121, p. 1517–1525
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