Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/113907
Title: Vitamin K dietary intake is associated with cognitive function in an older adult Mediterranean population
Authors: Camacho-Barcia, Lucía
García-Gavilán, Jesús
Martínez-González, Miguel Ángel
Fernández-Aranda, Fernando
Galié, Serena
Corella, Dolores
Cuenca-Royo, Aida
Romaguera, Dora
Vioque, Jesús
Alonso-Gómez, Ángel M.
Wärnberg, Julia
Martínez, J. Alfredo
Serra Majem, Luis 
Estruch, Ramón
Bernal-López, M. Rosa
Lapetra, José
Pintó, Xavier
Tur, Josep A.
Garcia-Rios, Antonio
Bueno-Cavanillas, Aurora
Delgado-Rodríguez, Miguel
Matía-Martín, Pilar
Daimiel, Lidia
Martín-Sánchez, Vicente
Vidal, Josep
Vázquez, Clotilde
Ros, Emilio
Canela, Miguel Ruiz
Sorlí, Jose V.
de la Torre, Rafael
Konieczna, Jadwiga
Oncina-Cánovas, Alejandro
Tojal-Sierra, Lucas
Pérez-López, Jessica
Abete, Itziar
Sánchez Villegas, Almudena 
Casas, Rosa
Muñoz-Garach, Araceli
Santos-Lozano, José Manuel
Bouzas, Cristina
Razquin, Cristina
Martínez-Lacruz, Raúl
Castañer, Olga
Yañez, Aina M.
Valls-Enguix, Rafael
Belló-Mora, Maria Concepción
Basterra-Gortari, Javier
Basora, Josep
Salas-Salvadó, Jordi
Bulló, Mònica
UNESCO Clasification: 32 Ciencias médicas
3206 Ciencias de la nutrición
Keywords: Cognitive Impairment
Cognitive-Neuropsychological Tests
Older People
Phylloquinone
Vitamin K
Issue Date: 2022
Project: Efecto de la dieta mediterránea hopocalórica y promoción de la actividad física en prevención primaria cardiovascular.Estudio piloto sobre marcadores intermedios. 
Efecto de Una Pérdida de Peso Con Dieta Mediterránea Hipocalórica y Promoción de la Actividad Física en la Prevención Primaria Cardiovascular 
Journal: Age and ageing 
Abstract: BACKGROUND: In the last years, evidence that dietary vitamin K could have a role in the cognitive domain has increased. However, data from large trials are limited. The objective of this study was to assess the association of 2 year changes in the dietary intake of vitamin K with cognitive function measured through neuropsychological performance tests. METHODS: In 5,533 participants of the multicentre PREDIMED-Plus study (48.1% women, age 65.1 ± 4.9 years with overweight/obesity and metabolic syndrome), we assessed the adjusted odds ratios of cognitive function decline according to 2 year changes in vitamin K intake. Participants answered a battery of cognitive function tests and Food Frequency Questionnaires (FFQs) in order to estimate the vitamin K dietary intake. RESULTS: After adjusting for potential cofounders, the highest tertile of change of dietary vitamin K intake (median [IQR]; 194.4 μg/d [120.9, 373.1]) was inversely associated with a Mini-Mental State Examination (MMSE) score ≤24 (OR [95% CI]; 0.53 [0.35, 0.79] P for trend = 0.002) compared with a decrease in the intake of vitamin K (median [IQR]; -97.8 μg/d [-292.8, -51.5]). A significant positive association between changes in dietary vitamin K intake and the semantic verbal fluency test scores (OR [95% CI]; 0.69 [0.51, 0.94] P for trend = 0.019) was found. CONCLUSIONS: An increase of the intake of dietary vitamin K was associated with better cognitive function scores, independently of recognised risk factors for cognitive decline, in an older adult Mediterranean population with high cardiovascular risk.
URI: http://hdl.handle.net/10553/113907
DOI: 10.1093/ageing/afab246
Source: Age and ageing[EISSN 1468-2834],v. 51 (2), (Febrero 2022)
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