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Title: Physical fitness and physical activity association with cognitive function and quality of life: baseline cross-sectional analysis of the PREDIMED-Plus trial
Authors: Daimiel, L
Martinez-Gonzalez, MA
Corella, D
Salas-Salvado, J
Schroder, H
Vioque, J
Romaguera, D
Martinez, JA
Warnberg, J
Lopez-Miranda, J
Estruch, R
Cano-Ibanez, N
Alonso-Gomez, A
Tur, JA
Tinahones, FJ
Serra Majem, Luis 
Mico-Perez, RM
Lapetra, J
Galdon, A
Pinto, X
Vidal, J
Mico, V
Colmenarejo, G
Gaforio, JJ
Matia, P
Ros, E
Buil-Cosiales, P
Vazquez-Ruiz, Z
Sorli, JV
Graniel, IP
Cuenca-Royo, A
Gisbert-Selles, C
Galmes-Panades, AM
Zulet, MA
Garcia-Rios, A
Diaz-Lopez, A
de la Torre, R
Galilea-Zabalza, I
Ordovas, JM
UNESCO Clasification: 32 Ciencias médicas
3206 Ciencias de la nutrición
3202 Epidemologia
Issue Date: 2020
Project: Efecto de una intervención intensiva de pérdida de peso con dieta Mediterránea hipocalórica, actividad física y tratamiento conductual sobre la prevención primaria cardiovascular: ensayo PREDIMED-Plus 
Efecto de Una Pérdida de Peso Con Dieta Mediterránea Hipocalórica y Promoción de la Actividad Física en la Prevención Primaria Cardiovascular 
Efecto de la dieta mediterránea hopocalórica y promoción de la actividad física en prevención primaria cardiovascular.Estudio piloto sobre marcadores intermedios. 
Journal: Scientific Reports 
Abstract: Physical activity (PA) has been hypothesized to be effective to maintaining cognitive function and delay cognitive decline in the elderly, but physical fitness (PF) could be a better predictor of cognitive function. We aimed to study the association between PA and PF with cognitive function and quality of life using cross-sectional data from 6874 participants of the PREDIMED-Plus trial (64.9 ± 4.9 years, 48.5% female). PF and PA were measured with a Chair Stand Test, the REGICOR and Rapid Assessment Physical Activity questionnaires. Cognitive function was measured with Mini-mental State Examination, Control Oral Word Association Test, Trail Making Test and Digit Span tests; whereas health-related quality of life was assessed with the SF36-HRQL test. Cognitive and quality of life scores were compared among PF quartiles and PA levels (low, moderate and high) with ANCOVA and with Chair Stand repetitions and energy expenditure from total PA with multivariable linear regression adjusted for confounding factors. PF associated with higher scores in phonemic and semantic verbal fluency tests and with lower TMT A time. However, PA was not associated with the neurocognitive parameters evaluated. Both PF and PA levels were strongly associated with a better quality of life. We concluded that PF, but not PA, is associated with a better cognitive function. This trial was retrospectively registered at the International Standard Randomized Controlled Trial (ISRCTN89898870, on 07/24/2014.
ISSN: 2045-2322
DOI: 10.1038/s41598-020-59458-6
Source: Scientific Reports [ISSN 2045-2322], v. 10(1), 3472 (Febrero 2020)
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