Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/112674
Título: Consumption of caffeinated beverages and kidney function decline in an elderly Mediterranean population with metabolic syndrome
Autores/as: Diaz-Lopez, A
Paz-Graniel, I
Ruiz, V
Toledo, E
Becerra-Tomas, N
Corella, D
Castaner, O
Martinez, JA
Alonso-Gomez, AM
Warnberg, J
Vioque, J
Romaguera, D
Lopez-Miranda, J
Estruch, R
Tinahones, FJ
Lapetra, J
Serra-Majem, Lluís 
Bueno-Cavanillas, A
Tur, JA
Sanchez, VM
Pinto, X
Delgado-Rodriguez, M
Matia-Martin, P
Vidal, J
Vázquez, Clotilde
Daimiel, L
Villa, TF
Ros, E
Eguaras, S
Babio, N
Sorli, JV
Goday, A
Abete, I
Sierra, LT
Baron-Lopez, FJ
Torres-Collado, L
Morey, M
Garcia-Rios, A
Casas, R
Bernal-Lopez, MR
Santos-Lozano, JM
Navarro Guerra,Ana 
Gonzalez, JI
Zomeno, MD
Zulet, MA
Luna, JV
Ramallal, R
Fito, M
Salas-Salvado, J
Clasificación UNESCO: 3206 Ciencias de la nutrición
Fecha de publicación: 2021
Publicación seriada: Scientific Reports 
Resumen: It remains unclear whether caffeinated beverages could have deleterious renal effects in elderly population with underlying comorbid conditions. We investigated the associations between coffee, tea, or caffeine intake and 1-year changes in glomerular filtration rate (eGFR) in a large Spanish cohort of overweight/obese elderly with metabolic syndrome (MetS). This prospective analysis includes 5851 overweight/obese adults (55–75 years) with MetS from the PREDIMED-Plus study. We assessed coffee, tea, and caffeine consumption from a validated food-frequency questionnaire and creatinine-based eGFR using the Chronic Kidney Disease Epidemiology Collaboration equation. Multivariate-adjusted regression models were applied to test associations between baseline coffee, tea, or caffeine intake and 1-year eGFR changes. Caffeinated coffee (> 2 cups/day) and tea (at least 1 cup/day) drinkers had 0.88 and 0.93 mL/min/1.73 m2 greater eGFR decrease respectively, compared to those with less than 1 cup/day of coffee consumption or non-tea drinkers. Furthermore, caffeinated coffee consumption of > 2 cups/day was associated with 1.19-fold increased risk of rapid eGFR decline > 3 mL/min/1.73 m2 (95% CI 1.01–1.41). Similarly, individuals in the highest (median, 51.2 mg/day) tertile of caffeine intake had a 0.87 mL/min/1.73 m2 greater eGFR decrease. Decaffeinated coffee was not associated with eGFR changes. In conclusion, higher consumption of caffeinated coffee, tea, and caffeine was associated with a greater 1-year eGFR decline in overweight/obese adults with MetS.
URI: http://hdl.handle.net/10553/112674
ISSN: 2045-2322
DOI: 10.1038/s41598-021-88028-7
Fuente: Scientific Reports [ISSN 2045-2322], v. 11 (1), (Diciembre 2021)
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