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Title: Platelet‐rich plasma for the treatment of degenerative lumbosacral stenosis: A study with retired working dogs
Authors: Hernández‐Guerra, Ángel María
Carrillo, José María
Sopena, Joaquín Jesús
Vilar Guereño, José Manuel 
Peláez, Pau
Cuervo, Belén
Santana del Pino, Ángelo 
Rubio, Mónica
UNESCO Clasification: 310904 Medicina interna
Keywords: Cauda Equina
Lumbosacral Estenosis
Platelet Rich‐Plasma
Issue Date: 2021
Journal: Animals 
Abstract: Traditionally, canine degenerative lumbosacral stenosis (DLS) has been defined as a mul-tifactorial syndrome characterized by lumbosacral pain triggered by the compression of the nerve rootlets of the cauda equina. There is still no consensus on the treatment of this condition, probably because there are a plethora of possible causes. In addition to compression, inflammation is a very important factor in the physiopathology of the disorder. Platelet‐rich plasma (PRP) consists of an increased concentration of autologous platelets suspended in a small amount of plasma. Platelets are a source of several growth factors. Growth factors were shown to help in wound healing and biological processes, such as chemotaxis, neovascularization and synthesis of extracellular matrix, and growth factors were used to improve soft tissue healing and bone regeneration. PRP also facil-itates the restoration of the structural integrity of the affected anatomy. Fourteen dogs diagnosed with DLS were treated with three epidural injections of PRP on days 0, 15 and 45. All dogs showed clinical improvement 3 months after the initial treatment. Gait was also objectively assessed by means of the use of force platform analysis before and after treatment, showing significant improve-ment. The results show that PRP may provide a good alternative to other nonsurgical treatments, such as prednisolone epidural injection.
ISSN: 2076-2615
DOI: 10.3390/ani11102965
Source: Animals [EISSN 2076-2615], v. 11 (10), 2965, (Octubre 2021)
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