Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/112138
Title: Piloleiomyosarcoma in cats: Histological and immunohistochemical features
Authors: Rodríguez Guisado, Francisco 
Castro Alonso, Pedro Luis 
UNESCO Clasification: 310907 Patología
240110 Histología animal
320713 Oncología
Keywords: Cat
Immunohistology
Integument
Piloleiomyosarcoma
Skin, et al
Issue Date: 2021
Journal: Veterinary Pathology 
Abstract: This study describes the histomorphology and immunohistochemical profile of 9 cases of feline piloleiomyosarcoma. Cats ranged in age from 7 to 16 years (mean 10), and tumors were 7 to 24 mm in diameter (mean 15). Tumors were composed of fusiform cells that were haphazardly arranged or in variably sized interwoven bundles. Neoplastic cells had eosinophilic and fibrillar cytoplasm, and elongated blunt-ended nuclei. Entrapment of hair follicles and absence of vascular components support an origin from the smooth muscle cells of the arrector pili. Additional findings included bizarre nuclei and giant cells (7/9 cases), atypical mitoses (7/9 cases), ulceration (3/9 cases), and intratumoral necrosis (6/9 cases). Neoplastic cells expressed calponin, desmin, α-smooth muscle actin, and vimentin, but not CD18, CD31, cytokeratins, glial fibrillary acidic protein, neuron-specific enolase, Melan A, p63, or S-100 protein. Surgical excision was curative in 6/9 cases, with local recurrence in 2/9 cases and metastasis to local lymph nodes in 1/9 case. Clinical outcome was influenced by mitotic count, infiltration of subcutaneous tissue, and intensity of nuclear immunolabeling for p53.
URI: http://hdl.handle.net/10553/112138
ISSN: 0300-9858
DOI: 10.1177/03009858211042582
Source: Veterinary Pathology [ISSN 0300-9858], September 2021
Appears in Collections:Artículos
Adobe PDF (1,36 MB)
Show full item record

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.