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Title: Impact of polypropylene microplastics and chemical pollutants on European sea bass (Dicentrarchus labrax) gut microbiota and health
Authors: Montero Vítores, Daniel 
Rimoldi, Simona
Torrecillas Burriel,Silvia 
Rapp Cabrera, Jorge 
Moroni, Federico
Herrera Ulibarri, Alicia 
Gómez, May 
Fernández Montero, Álvaro 
Terova, Genciana
UNESCO Clasification: 310502 Piscicultura
331210 Plásticos
330811 Control de la contaminación del agua
Keywords: Chemical pollutants
European sea bass
Gut microbiota
Ingestion, et al
Issue Date: 2022
Project: Implementation of the indicator Impacts of marine litter on sea turtles and biota in RSC and MSFD areas 
Journal: Science of the Total Environment 
Abstract: Plastic pollution has become a global problem for marine ecosystems. Microplastics (MPs) are consumed by several marine organisms, including benthic and pelagic fish species that confuse them with food sources, thus contributing to bioaccumulation along the food chain. In addition to structural intestinal damage, ingestion of MPs represents a pathway for fish exposure to potentially hazardous chemicals, too. Most of them are endocrine disrupters, genotoxic or induce immune depression in fish. Accordingly, we assessed the combined toxicological effects of microplastics (MPs) and adsorbed pollutants by adding them to marine fish diet. European sea bass (Dicentrarchus labrax) juveniles were fed for 60 days with feeds containing polypropylene MPs, either virgin or contaminated with chemical pollutants (a blend of dichlorodiphenyldichloroethylene, chlorpyrifos, and benzophenone-3). The data demonstrated a synergic action of MPs and chemical pollutants to induce an inflammatory-like response in distal intestine of sea bass as shown by the up regulation of cytokine il-6 and tnf-α expression. Morphological analysis detected the presence of a focus of lymphocytes in anterior and posterior intestinal segments of fish fed with contaminants in the diet. With regard to microbiota, significant changes in bacterial species richness, beta diversity, and composition of gut microbiota were observed as a consequence of both pollutants and polluted MPs ingestion. These perturbations in gut microbial communities, including the reduction of beneficial lactic acid bacteria and the increase in potential pathogenic microorganism (Proteobacteria and Vibrionales), were undeniable signs of intestinal dysbiosis, which in turn confirmed the signs of inflammation caused by pollutants, especially when combined with MPs. The results obtained in this study provide, therefore, new insights into the potential risks of ingesting MPs as pollutant carriers in marine fish.
ISSN: 0048-9697
DOI: 10.1016/j.scitotenv.2021.150402
Source: Science of The Total Environment [ISSN 0048-9697]. v. 805, 150402, (Enero 2022)
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