Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/107456
Title: Dietary vitamin D intake and colorectal cancer risk: a longitudinal approach within the PREDIMED study
Authors: Hernández-Alonso, Pablo
Canudas, Silvia
Boughanem, Hatim
Toledo, Estefanía
Sorlí, Jose V.
Estruch, Ramón
Castañer, Olga
Lapetra, José
Alonso-Gómez, Angel M.
Gutiérrez-Bedmar, Mario
Fiol, Miquel
Serra Majem, Luis 
Pintó, Xavier
Ros, Emilio
Fernandez-Lazaro, Cesar I.
Ramirez-Sabio, Judith B.
Fitó, Montse
Portu-Zapirain, Joseba
Macias-González, Manuel
Babio, Nancy
Salas-Salvadó, Jordi
UNESCO Clasification: 32 Ciencias médicas
3206 Ciencias de la nutrición
Keywords: Cancer
Colorectal Cancer
Predimed
Risk
Vitamin D
Issue Date: 2021
Project: The Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBEROBN) is an initiative of the Spanish Instituto de Salud Carlos III (ISCIII) which is funded by FEDER “A way to make Europe”/” Investing in your future” (CB06/03). It is supported by the official funding agency for biomedical research of the Spanish government, ISCIII, through grants provided to research networks specifically developed for the trial (RTIC G03/140 and RD 06/0045) through CIBEROBN, and by Grants from the Centro Nacional de Investigaciones Cardiovasculares (CNIC 06/2007), Fondo de Investigación Sanitaria–Fondo Europeo de Desarrollo Regional (PI04–2239, PI05/2584, CP06/00100, PI07/0240, PI07/1138, PI07/0954, PI07/0473, PI10/01407, PI10/02658, PI11/01647, and PI11/02505; PI13/00462 and PI18/01399), Ministerio de Ciencia e Innovación (AGL-2009–13906-C02 and AGL2010–22319-C03), Fundación Mapfre 2010, Consejería de Salud de la Junta de Andalucía (PI0105/2007), Public Health Division of the Department of Health of the Autonomous Government of Catalonia, Generalitat Valenciana (PROMETEO17/2017), and the Navarra Regional Government (27/2011). The Fundación Patrimonio Comunal Olivarero and Hojiblanca SA (Málaga, Spain), California Walnut Commission (Sacramento, CA), Borges SA (Reus, Spain), and Morella Nuts SA (Reus, Spain) donated the olive oil, walnuts, almonds, and hazelnuts, respectively, used in the study. JS-S, the senior author/gratefully acknowledges the financial support by ICREA under the ICREA Academia program. Dr. PH-A was supported by a postdoctoral fellowship (Juan de la Cierva-Formación, FJCI-2017-32205). None of the funding sources played a role in the design, collection, analysis or interpretation of the data or in the decision to submit the manuscript for publication. MM-G was the recipient of the Nicolas Monardes Programme from the “Servicio Andaluz de Salud, Junta de Andalucia”, Spain (RC-0001-2018 and C-0029-2023). This work is partially supported by ICREA under the ICREA Academia programme.
Journal: European Journal of Nutrition 
Abstract: Purpose: We evaluated whether the intake of dietary vitamin D is associated with the incidence of both colorectal cancer (CRC) and colon cancer in the framework of the PREDIMED cohort of older adults at high cardiovascular risk. Methods: We analyzed data from 7216 men and women (55–80 years) without CRC at baseline from the PREvención con DIeta MEDiterránea study. Baseline consumption of vitamin D was assessed using a validated 137-item food frequency questionnaire. Cox proportional hazards ratios (HRs) of CRC and colon cancer incidence were estimated for quartiles and per 1-SD of baseline vitamin D intake. Results: During a median follow-up of 6 years, we documented 97 incident CRC cases after the exclusion of subjects with no baseline dietary data and/or outliers of energy intake. A non-significant HRs and 95% confidence intervals (CIs) of CRC for the comparison of extreme quartiles (4th vs 1st) of vitamin D intake were observed [0.55 (0.30–1.00), P for trend = 0.072], whereas it was significant for colon cancer incidence alone [0.44 (0.22–0.90), P for trend = 0.032]. However, this association became significant in CRC and colon cancer incidence, after excluding 391 subjects consuming baseline vitamin D and/or calcium medication or prescribed supplements [0.52 (0.28–0.96) and 0.41 (0.12–0.85), respectively]. Conclusion: A higher dietary intake of vitamin D was significantly associated with a reduced CRC risk in individuals at high cardiovascular risk.
URI: http://hdl.handle.net/10553/107456
ISSN: 1436-6207
DOI: 10.1007/s00394-021-02585-1
Source: European Journal of Nutrition[ISSN 1436-6207], n. 60, p. 4367–4378, (Mayo 2021)
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