Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/107456
Title: Dietary vitamin D intake and colorectal cancer risk: a longitudinal approach within the PREDIMED study
Authors: Hernández-Alonso, Pablo
Canudas, Silvia
Boughanem, Hatim
Toledo, Estefanía
Sorlí, Jose V.
Estruch, Ramón
Castañer, Olga
Lapetra, José
Alonso-Gómez, Angel M.
Gutiérrez-Bedmar, Mario
Fiol, Miquel
Serra Majem, Luis 
Pintó, Xavier
Ros, Emilio
Fernandez-Lazaro, Cesar I.
Ramirez-Sabio, Judith B.
Fitó, Montse
Portu-Zapirain, Joseba
Macias-González, Manuel
Babio, Nancy
Salas-Salvadó, Jordi
UNESCO Clasification: 32 Ciencias médicas
3206 Ciencias de la nutrición
Keywords: Cancer
Colorectal Cancer
Predimed
Risk
Vitamin D
Issue Date: 2021
Journal: European Journal of Nutrition 
Abstract: Purpose: We evaluated whether the intake of dietary vitamin D is associated with the incidence of both colorectal cancer (CRC) and colon cancer in the framework of the PREDIMED cohort of older adults at high cardiovascular risk. Methods: We analyzed data from 7216 men and women (55–80 years) without CRC at baseline from the PREvención con DIeta MEDiterránea study. Baseline consumption of vitamin D was assessed using a validated 137-item food frequency questionnaire. Cox proportional hazards ratios (HRs) of CRC and colon cancer incidence were estimated for quartiles and per 1-SD of baseline vitamin D intake. Results: During a median follow-up of 6 years, we documented 97 incident CRC cases after the exclusion of subjects with no baseline dietary data and/or outliers of energy intake. A non-significant HRs and 95% confidence intervals (CIs) of CRC for the comparison of extreme quartiles (4th vs 1st) of vitamin D intake were observed [0.55 (0.30–1.00), P for trend = 0.072], whereas it was significant for colon cancer incidence alone [0.44 (0.22–0.90), P for trend = 0.032]. However, this association became significant in CRC and colon cancer incidence, after excluding 391 subjects consuming baseline vitamin D and/or calcium medication or prescribed supplements [0.52 (0.28–0.96) and 0.41 (0.12–0.85), respectively]. Conclusion: A higher dietary intake of vitamin D was significantly associated with a reduced CRC risk in individuals at high cardiovascular risk.
URI: http://hdl.handle.net/10553/107456
ISSN: 1436-6207
DOI: 10.1007/s00394-021-02585-1
Source: European Journal of Nutrition[ISSN 1436-6207], (Mayo 2021)
Appears in Collections:Artículo preliminar
Show full item record

Page view(s)

71
checked on Jul 31, 2021

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.