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Title: Dietary vitamin D intake and colorectal cancer risk: a longitudinal approach within the PREDIMED study
Authors: Hernández-Alonso, Pablo
Canudas, Silvia
Boughanem, Hatim
Toledo, Estefanía
Sorlí, Jose V.
Estruch, Ramón
Castañer, Olga
Lapetra, José
Alonso-Gómez, Angel M.
Gutiérrez-Bedmar, Mario
Fiol, Miquel
Serra Majem, Luis 
Pintó, Xavier
Ros, Emilio
Fernandez-Lazaro, Cesar I.
Ramirez-Sabio, Judith B.
Fitó, Montse
Portu-Zapirain, Joseba
Macias-González, Manuel
Babio, Nancy
Salas-Salvadó, Jordi
UNESCO Clasification: 32 Ciencias médicas
3206 Ciencias de la nutrición
Keywords: Cancer
Colorectal Cancer
Vitamin D
Issue Date: 2021
Journal: European Journal of Nutrition 
Abstract: Purpose: We evaluated whether the intake of dietary vitamin D is associated with the incidence of both colorectal cancer (CRC) and colon cancer in the framework of the PREDIMED cohort of older adults at high cardiovascular risk. Methods: We analyzed data from 7216 men and women (55–80 years) without CRC at baseline from the PREvención con DIeta MEDiterránea study. Baseline consumption of vitamin D was assessed using a validated 137-item food frequency questionnaire. Cox proportional hazards ratios (HRs) of CRC and colon cancer incidence were estimated for quartiles and per 1-SD of baseline vitamin D intake. Results: During a median follow-up of 6 years, we documented 97 incident CRC cases after the exclusion of subjects with no baseline dietary data and/or outliers of energy intake. A non-significant HRs and 95% confidence intervals (CIs) of CRC for the comparison of extreme quartiles (4th vs 1st) of vitamin D intake were observed [0.55 (0.30–1.00), P for trend = 0.072], whereas it was significant for colon cancer incidence alone [0.44 (0.22–0.90), P for trend = 0.032]. However, this association became significant in CRC and colon cancer incidence, after excluding 391 subjects consuming baseline vitamin D and/or calcium medication or prescribed supplements [0.52 (0.28–0.96) and 0.41 (0.12–0.85), respectively]. Conclusion: A higher dietary intake of vitamin D was significantly associated with a reduced CRC risk in individuals at high cardiovascular risk.
ISSN: 1436-6207
DOI: 10.1007/s00394-021-02585-1
Source: European Journal of Nutrition[ISSN 1436-6207], (Mayo 2021)
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