Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/107271
Title: Ozone therapy versus surgery for lumbar disc herniation: A randomized double-blind controlled trial
Authors: Clavo, Bernardino 
Robaina, Francisco 
Urrutia, Gerard
Bisshopp, Sara 
Ramallo, Yolanda 
Szolna, Adam 
Caramés, Miguel A. 
Fiuza, María D. 
Linertová, Renata
UNESCO Clasification: 32 Ciencias médicas
3201 Ciencias clínicas
Keywords: Cost-Effectiveness
Disc Herniation
Microdiscectomy
Ozone Therapy
Randomized Controlled Trial
Issue Date: 2021
Journal: Complementary Therapies in Medicine 
Abstract: Objectives: Surgery is the treatment of choice for symptomatic disc herniation after conservative management. Several studies have suggested the potential utility of intradiscal ozone infiltration in this pathology. The aim of this trial was to compare intradiscal ozone infiltration vs. oxygen infiltration vs. surgery. Design and interventions: This was a randomized, double-blinded, and controlled trial in patients on a waiting list for herniated disc surgery. There were three treatment groups: surgery; intradiscal ozone infiltration (plus foraminal infiltration of ozone, steroids, and anesthetic); intradiscal oxygen infiltration (plus foraminal infiltration of oxygen, steroids, and anesthetic). Main outcome measures: The requirements for surgery. Results: Five years after the treatment of the last recruited patient (median follow-up: 78 months), the requirement for further surgery was 20 % for patients in the ozone group and 60 % for patients in the oxygen group. 11 % of patients initially treated with surgery also required a second surgery. Compared to the surgery group, the ozone group showed: 1) significantly lower number of inpatient days: median 3 days (interquartile range: 3–3.5 days) vs. 0 days (interquartile range: 0–1.5 days), p = 0.012; 2) significantly lower costs: median EUR 3702 (interquartile range: EUR 3283–7630) vs. EUR 364 (interquartile range: EUR 364–2536), p = 0.029. Conclusions: Our truncated trial showed that intradiscal ozone infiltrations decreased the requirements for conventional surgery, resulting in decreased hospitalization durations and associated costs. These findings and their magnitude are of interest to patients and health services providers. Further validation is ongoing.
URI: http://hdl.handle.net/10553/107271
ISSN: 0965-2299
DOI: 10.1016/j.ctim.2021.102724
Source: Complementary Therapies in Medicine [ISSN 0965-2299], v. 59, 102724, (Junio 2021)
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