Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/107237
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dc.contributor.authorQuintana, Mercedesen_US
dc.contributor.authorSaavedra Díaz, Ester Gloriaen_US
dc.contributor.authorDel Rosario García, Henocen_US
dc.contributor.authorGonzález, Ignacioen_US
dc.contributor.authorHernández González, Inmaculada Servandaen_US
dc.contributor.authorEstévez Rosas, Francisco Jesúsen_US
dc.contributor.authorQuintana Aguiar, José Martínen_US
dc.date.accessioned2021-05-19T13:53:49Z-
dc.date.available2021-05-19T13:53:49Z-
dc.date.issued2021en_US
dc.identifier.issn1422-0067en_US
dc.identifier.urihttp://hdl.handle.net/10553/107237-
dc.description.abstractEthanol has been shown to exhibit therapeutic properties as an ablative agent alone and in combination with thermal ablation. Ethanol may also increase sensitivity of cancer cells to certain physical and chemical antitumoral agents. The aim of our study was to assess the potential influence of nontoxic concentrations of ethanol on hyperthermia therapy, an antitumoral modality that is continuously growing and that can be combined with classical chemotherapy and radiotherapy to improve their efficiency. Human leukemia cells were included as a model in the study. The results indicated that ethanol augments the cytotoxicity of hyperthermia against U937 and HL60 cells. The therapeutic benefit of the hyperthermia/ethanol combination was associated with an increase in the percentage of apoptotic cells and activation of caspases-3, -8 and -9. Apoptosis triggered either by hyperthermia or hyperthermia/ethanol was almost completely abolished by a caspase-8 specific inhibitor, indicating that this caspase plays a main role in both conditions. The role of caspase-9 in hyperthermia treated cells acquired significance whether ethanol was present during hyperthermia since the alcohol enhanced Bid cleavage, translocation of Bax from cytosol to mitochondria, release of mitochondrial apoptogenic factors, and decreased of the levels of the anti-apoptotic factor myeloid cell leukemia-1 (Mcl-1). The enhancement effect of ethanol on hyperthermia-activated cell death was associated with a reduction in the expression of HSP70, a protein known to interfere in the activation of apoptosis at different stages. Collectively, our findings suggest that ethanol could be useful as an adjuvant in hyperthermia therapy for cancer.en_US
dc.languageengen_US
dc.relationEvaluación de Endemismos Canarios Como Fuente de Biomoléculas de Interés Medicoen_US
dc.relation.ispartofInternational Journal of Molecular Sciencesen_US
dc.sourceInternational Journal of Molecular Sciences [ISSN 1422-0067], v. 22(9), 4948, (Mayo 2021)en_US
dc.subject32 Ciencias médicasen_US
dc.subject241003 Citología humanaen_US
dc.subject2302 Bioquímicaen_US
dc.subject.otherEthanolen_US
dc.subject.otherHyperthermiaen_US
dc.subject.otherLeukemia cellsen_US
dc.subject.otherApoptosisen_US
dc.subject.otherHSP70en_US
dc.titleEthanol enhances hyperthermia‐induced cell death in human leukemia cellsen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typearticleen_US
dc.identifier.doi10.3390/ijms22094948en_US
dc.identifier.pmid34066632-
dc.identifier.scopus2-s2.0-85105156850-
dc.contributor.orcid#NODATA#-
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dc.contributor.orcid#NODATA#-
dc.identifier.issue9-
dc.relation.volume22en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
local.message.claim2024-05-09T17:00:32.292+0100|||rp01023|||submit_approve|||dc_contributor_author|||No soy coautora de esta publicación, ruego eliminar de la lista*
dc.description.numberofpages20en_US
dc.utils.revisionen_US
dc.date.coverdateMayo 2021en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,176
dc.description.jcr6,208
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
dc.description.miaricds10,8
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.orcid0000-0002-1717-386X-
crisitem.author.orcid0000-0001-8937-9034-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.orcid0000-0001-8225-4538-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSaavedra Díaz, Ester Gloria-
crisitem.author.fullNameDel Rosario García, Henoc-
crisitem.author.fullNameHernández González, Inmaculada Servanda-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
crisitem.author.fullNameQuintana Aguiar, José Martín-
crisitem.project.principalinvestigatorEstévez Rosas, Francisco Jesús-
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