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Title: Aberrant Expression of Cell Cycle Regulator 14-3-3-σ and E-Cadherin in a Metastatic Cholangiocarcinoma in a Vervet Monkey (Chlorocebus pygerythrus)
Authors: Suárez Bonnet, Alejandro 
Priestnall, S.L.
Ramírez, G.A.
Molín, J.
Jáber Mohamad, José Raduán 
UNESCO Clasification: 310904 Medicina interna
320713 Oncología
Keywords: 14-3-3σ
Non-human primate
Issue Date: 2020
Journal: Journal of Comparative Pathology 
Abstract: We present a unique case of metastatic cholangiocarcinoma with concurrent abdominal cestodiasis in an African green monkey (Chlorocebus pygerythrus) that presented with respiratory insufficiency and abdominal discomfort. There were multiple white–grey masses in the liver and colonic serosa alongside intra-abdominal parasitic cysts. Histopathologically, the liver masses were composed of poorly-differentiated epithelial cells that formed densely cellular solid areas and trabeculae. The neoplastic cells were strongly immunopositive for CK7 but negative for Hep-Par1 antigen, which confirmed a diagnosis of cholangiocarcinoma. Interestingly, there was strong and diffuse neoexpression in the tumour of the cell cycle regulator 14-3-3σ, which is not constitutively expressed in normal liver. There was aberrantly strong expression of E-cadherin, a key cell–cell adhesion protein, in neoplastic cells with evidence of cytoplasmic internalization. This is the first immunohistochemical analysis of 14-3-3σ and E-cadherin in a liver neoplasm in an animal species and the use of these markers requires further investigation in animal liver neoplasms.
ISSN: 0021-9975
DOI: 10.1016/j.jcpa.2020.07.001
Source: Journal of Comparative Pathology [ISSN 0021-9975], n. 179, p. 25-30, (Agosto 2020)
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