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Title: An Easy Procedure to Quantify Anticoagulant Rodenticides and Pharmaceutical Active Compounds in Soils
Authors: Acosta Dacal, Andrea Carolina 
Rial Berriel, Cristian Javier 
Díaz-Díaz, Ricardo
Bernal-Suárez, María del Mar
Zumbado Peña, Manuel Luis 
Henríquez Hernández, Luis Alberto 
Pérez Luzardo, Octavio Luis 
UNESCO Clasification: 32 Ciencias médicas
3214 Toxicología
Keywords: Brodifacoum
Veterinary drugs
LC-MS/MS, et al
Issue Date: 2021
Journal: Toxics 
Abstract: A modified QuEChERS (quick, easy, cheap, effective, rugged, and safe) extraction was validated for the extraction of seven coumarin anticoagulant rodenticides (ARs) and 36 pharmaceutical active compounds (PhACs) residues in soil samples using liquid chromatography tandem mass spectrometry (LC-MS/MS). The aim of this work was to develop a method for the monitoring of these compounds in agricultural lands as well as in forensic applications for the determination of ARs poisoning. As far as is known, this is the first time that a QuEChERS-based method is used for the extraction of ARs in soil, as well as on such a quantity of PhACs. A matrix effect study was carried out on samples of soil devoted to agriculture in the midland area of the Canary Islands (clay loam type). It was in house validated (accuracy, precision, and linearity) at seven spiked levels between 0.5 and 50 ng g􀀀1. The limits of quantification (LOQ) ranged between 0.5 and 50.0 ng g􀀀1 and the limits of detection (LOD) ranged from 0.024 to 6.25 ng g􀀀1. The method was then successfully used for both the determination of the target analytes in the soils from the agricultural plots that had been irrigated with regenerated water, and in the soil collected from underneath wild bird carcasses (which had been the subject of forensic investigation).
ISSN: 2305-6304
DOI: 10.3390/toxics9040083
Source: Toxics [ISSN 2305-6304], v.9 (4), 83, (Abril 2021)
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