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Title: Serum levels of glutamate-pyruvate transaminase, glutamate-oxaloacetate transaminase and gamma-glutamyl transferase in 1494 patients with various genotypes for the alpha-1 antitrypsin gene
Authors: Hernández Pérez, José María
Blanco, Ignacio
Sánchez Medina, Agustín Jesús 
Díaz Hernández, Laura
Pérez Pérez, José Antonio
UNESCO Clasification: 531207 Sanidad
Keywords: Enfermedades del hígado
Issue Date: 2020
Journal: Journal of Clinical Medicine 
Abstract: Background: Patients with liver disease associated with alpha-1 antitrypsin deficiency (AATD) are homozygous for the Z mutation, leading to chronic liver damage. Objective: To assess the serum levels of glutamate-oxaloacetate transaminase (GOT), glutamate-pyruvate transaminase (GPT), and gamma-glutamyl transpeptidase (GGT) in patients with different genotypes for the alpha-1 antitrypsin (AAT) gene. Methods: Patients (n = 1494) underwent genotyping of the SERPINA1 gene, together with a determination of AAT and GOT and GPT and GGT transaminase levels. Patients with a deficient allele (n = 476) and with a normal genotype were compared. Results: A statistically significant association was found between deficient genotypes and GOT (p < 0.0003), GPT (p < 0.002), and GGT (p < 0.006). Comparing GOT levels in patients with PI*Z deficient variant versus those with normal genotype, an odds ratio (OR) of 2.72 (CI: 1.5–4.87) (p < 0.0005) was obtained. This finding was replicated with the PI*Z allele and the GPT values (OR = 2.31; CI: 1.45–3.67; p < 0.0003). In addition, a statistically significant association was found between liver enzymes and AAT values. Conclusion: The PI*Z allele seemed to be a risk factor for the development of liver damage. AAT deficient genotypes were associated with GOT, GPT, and GGT altered values. Low AAT levels were associated with high GPT and GGT levels
ISSN: 2077-0383
DOI: 10.3390/jcm9123923
Source: Journal of Clinical Medicine, 2020, 9(12), 3923
Appears in Collections:Artículos
Hernández Perez, J., Blanco, I., Sánchez-Medina, A.J., Díaz Hernández, L., y Pérez Pérez, A. (2020). Serum Levels of Glutamate-Pyruvate Transaminase, Glutamate-Oxaloacetate Transaminase and Gamma-Glutamyl Transferase in 1494 Patients with Various Genotypes for the Alpha-1 Antitrypsin Gene. Journal of Clinical Medicine. 9. ISSN 2077-0383 (Índice de impacto: 3,303; 36 de 156; Q1)
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