Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/106066
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Rodríguez Guisado, Francisco | en_US |
dc.contributor.author | Suárez Bonnet, Alejandro | en_US |
dc.contributor.author | Ramírez, Gustavo A. | en_US |
dc.date.accessioned | 2021-03-22T14:37:59Z | - |
dc.date.available | 2021-03-22T14:37:59Z | - |
dc.date.issued | 2021 | en_US |
dc.identifier.issn | 0300-9858 | en_US |
dc.identifier.uri | http://hdl.handle.net/10553/106066 | - |
dc.description.abstract | This study describes the clinical and pathological characteristics of cutaneous spindle cell squamous cell carcinoma (SCSCC) in 18 cats. The average age of the cats was 11.8 ± 2.7 years, and all tumors were located in the facial skin, mainly affecting the pinna (13/18, 72%), followed by the periorbital area (4/18, 22%) and the dorsal muzzle (1/18, 6%). Tumors were composed of fusiform neoplastic cells with moderate atypia arranged in solid sheets or fascicles with foci of squamous differentiation. A panel of antibodies against cytokeratins, vimentin, S-100 protein, NSE, GFAP, Melan A, SMA, desmin, CD18, CD31, and p63 was used to help differentiate SCSCC from other spindle cell malignancies. SCSCCs expressed CK5/6 (17/18, 94%), AE1/AE3 (15/18, 83%), and p63 protein (18/18, 100%), but there was no immunolabeling for CK8/18. A role for sunlight exposure in the pathogenesis of the tumors was suggested by changes indicative of actinic keratosis, the location of the tumors in dorsal areas, and the absence of histomorphologic features of papillomavirus infection. Recurrence was not recorded in 14/18 cases (78%) during a follow-up period of 7 to 25 months. Three of 18 (17%) tumors recurred or led to humane euthanasia due to local progression, and one case (5%) had regional lymph node metastasis. Clinical outcome varied with cutaneous location, mitotic count, and invasion of surgical margins; thus, SCSCCs with a more aggressive behavior were located in the periorbital area (4/4 cases), had ≥14 mitoses in 10 high-power fields (2.37 mm2) (4/4 cases), and showed invasion of surgical margins (3/4 cases). | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Veterinary Pathology | en_US |
dc.source | Veterinary Pathology [ISSN 1544-2217], v. 58(3), February 2021 | en_US |
dc.subject | 310907 Patología | en_US |
dc.subject | 320713 Oncología | en_US |
dc.subject.other | Actinic | en_US |
dc.subject.other | Cat | en_US |
dc.subject.other | Cytokeratins | en_US |
dc.subject.other | Immunohistochemistry | en_US |
dc.subject.other | Integument | en_US |
dc.subject.other | Sarcomatoid | en_US |
dc.subject.other | Spindle cell | en_US |
dc.subject.other | Squamous cell carcinoma | en_US |
dc.title | Cutaneous Spindle Cell Squamous Cell Carcinoma in Cats: Clinical, Histological, and Immunohistochemical Study | en_US |
dc.type | info:eu-repo/semantics/article | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1177/0300985820985126 | en_US |
dc.investigacion | Ciencias de la Salud | en_US |
dc.type2 | Artículo | en_US |
dc.utils.revision | Sí | en_US |
dc.identifier.ulpgc | Sí | en_US |
dc.contributor.buulpgc | BU-VET | en_US |
dc.description.sjr | 0,768 | |
dc.description.jcr | 3,157 | |
dc.description.sjrq | Q1 | |
dc.description.jcrq | Q1 | |
dc.description.scie | SCIE | |
dc.description.miaricds | 11,0 | |
item.grantfulltext | none | - |
item.fulltext | Sin texto completo | - |
crisitem.author.dept | GIR IUSA-ONEHEALTH1: Epidemiología, Medicina Preventiva Veterinaria y Zoonosis | - |
crisitem.author.dept | IU de Sanidad Animal y Seguridad Alimentaria | - |
crisitem.author.dept | Departamento de Morfología | - |
crisitem.author.dept | GIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina) | - |
crisitem.author.dept | IU de Sanidad Animal y Seguridad Alimentaria | - |
crisitem.author.orcid | 0000-0002-4968-5333 | - |
crisitem.author.parentorg | IU de Sanidad Animal y Seguridad Alimentaria | - |
crisitem.author.parentorg | IU de Sanidad Animal y Seguridad Alimentaria | - |
crisitem.author.fullName | Rodríguez Guisado, Francisco | - |
crisitem.author.fullName | Suarez Bonnet,Alejandro | - |
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