Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/106066
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dc.contributor.authorRodríguez Guisado, Franciscoen_US
dc.contributor.authorSuárez Bonnet, Alejandroen_US
dc.contributor.authorRamírez, Gustavo A.en_US
dc.date.accessioned2021-03-22T14:37:59Z-
dc.date.available2021-03-22T14:37:59Z-
dc.date.issued2021en_US
dc.identifier.issn0300-9858en_US
dc.identifier.urihttp://hdl.handle.net/10553/106066-
dc.description.abstractThis study describes the clinical and pathological characteristics of cutaneous spindle cell squamous cell carcinoma (SCSCC) in 18 cats. The average age of the cats was 11.8 ± 2.7 years, and all tumors were located in the facial skin, mainly affecting the pinna (13/18, 72%), followed by the periorbital area (4/18, 22%) and the dorsal muzzle (1/18, 6%). Tumors were composed of fusiform neoplastic cells with moderate atypia arranged in solid sheets or fascicles with foci of squamous differentiation. A panel of antibodies against cytokeratins, vimentin, S-100 protein, NSE, GFAP, Melan A, SMA, desmin, CD18, CD31, and p63 was used to help differentiate SCSCC from other spindle cell malignancies. SCSCCs expressed CK5/6 (17/18, 94%), AE1/AE3 (15/18, 83%), and p63 protein (18/18, 100%), but there was no immunolabeling for CK8/18. A role for sunlight exposure in the pathogenesis of the tumors was suggested by changes indicative of actinic keratosis, the location of the tumors in dorsal areas, and the absence of histomorphologic features of papillomavirus infection. Recurrence was not recorded in 14/18 cases (78%) during a follow-up period of 7 to 25 months. Three of 18 (17%) tumors recurred or led to humane euthanasia due to local progression, and one case (5%) had regional lymph node metastasis. Clinical outcome varied with cutaneous location, mitotic count, and invasion of surgical margins; thus, SCSCCs with a more aggressive behavior were located in the periorbital area (4/4 cases), had ≥14 mitoses in 10 high-power fields (2.37 mm2) (4/4 cases), and showed invasion of surgical margins (3/4 cases).en_US
dc.languageengen_US
dc.relation.ispartofVeterinary Pathologyen_US
dc.sourceVeterinary Pathology [ISSN 1544-2217], v. 58(3), February 2021en_US
dc.subject310907 Patologíaen_US
dc.subject320713 Oncologíaen_US
dc.subject.otherActinicen_US
dc.subject.otherCaten_US
dc.subject.otherCytokeratinsen_US
dc.subject.otherImmunohistochemistryen_US
dc.subject.otherIntegumenten_US
dc.subject.otherSarcomatoiden_US
dc.subject.otherSpindle cellen_US
dc.subject.otherSquamous cell carcinomaen_US
dc.titleCutaneous Spindle Cell Squamous Cell Carcinoma in Cats: Clinical, Histological, and Immunohistochemical Studyen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typearticleen_US
dc.identifier.doi10.1177/0300985820985126en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.utils.revisionen_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-VETen_US
dc.description.sjr0,768
dc.description.jcr3,157
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
dc.description.miaricds11,0
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUSA-ONEHEALTH1: Epidemiología, Medicina Preventiva Veterinaria y Zoonosis-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptGIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina)-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.orcid0000-0002-4968-5333-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.fullNameRodríguez Guisado, Francisco-
crisitem.author.fullNameSuarez Bonnet,Alejandro-
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