Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/71701
Título: Bisphosphonate-associated osteonecrosis of the jaw: a proposal for conservative treatment
Autores/as: Bocanegra Pérez, Sacramento
Vicente Barrero, Mario 
Sosa Hernández, Manuel
Knezevic, Milan
Castellano Navarro, José María
Rodríguez Millares, José
Clasificación UNESCO: 320714 Osteopatología
321313 Ortodoncia-estomatología
Palabras clave: Maxillary osteonecrosis
Bisphosphonates
Zoledronic acid
Zoledronate
Extraoral fistulation
Fecha de publicación: 2008
Publicación seriada: Medicina Oral, Patologia Oral y Cirugia Bucal 
Resumen: The use of bisphosphonates (BPs) has proven effective in the treatment of bone-related diseases, despite the potential risk of developing osteonecrosis of the jaw (ONJ). So far, results for the treatment of ONJ have not been satisfactory. In our study, we have treated two patients diagnosed with ONJ. In addition to local treatments a hydrogel was applied, with promising results. The fistulae disappeared 2-3 weeks into the treatment. After a six-month follow-up period there has been no sign of recurrence. The extent of maxillary bone exposure has diminished notably, although not entirely disappeared. In all cases, the patients exhibit no other symptoms (they suffer from no pain or swelling or functional impotence). For this reason we believe this protocol might be useful in the case of patients who suffer from pain and fistulation secondary to BP-associated ONJ to improve the state of their lesions until definitive treatment can be undertaken. Although these findings are not conclusive, given that we are reporting data on two patients only, we believe that this might be an alternative treatment in refractory cases where other therapies are counter-indicated. A controlled randomized and prospective study would be required to confirm our findings.
URI: http://hdl.handle.net/10553/71701
ISSN: 1698-6946
Fuente: Medicina oral, patología oral y cirugía bucal. Ed. inglesa [ISSN 1698-6946], v. 13 (12), p. 5-0
URL: http://dialnet.unirioja.es/servlet/articulo?codigo=5989366
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