Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/55021
Título: Diabetes in pregnancy and microRNAs: Promises and limitations in their clinical application
Autores/as: Ibarra, Adriana
Vega-Guedes, Begoña 
Brito-Casillas, Yeray 
Wägner, Ana M. 
Clasificación UNESCO: 320602 Metabolismo energético
320102 Genética clínica
320708 Hematología
320108 Ginecología
Palabras clave: Intrauterine programming
Pre-gestational diabetes
Gestational diabetes
Diabetic embryopathy
Macrosomia
Fecha de publicación: 2018
Publicación seriada: Non-coding RNA 
Resumen: Maternal diabetes is associated with an increased risk of complications for the mother and her offspring. The latter have an increased risk of foetal macrosomia, hypoglycaemia, respiratory distress syndrome, preterm delivery, malformations and mortality but also of life-long development of obesity and diabetes. Epigenetics have been proposed as an explanation for this long-term risk, and microRNAs (miRNAs) may play a role, both in short- and long-term outcomes. Gestation is associated with increasing maternal insulin resistance, as well as β-cell expansion, to account for the increased insulin needs and studies performed in pregnant rats support a role of miRNAs in this expansion. Furthermore, several miRNAs are involved in pancreatic embryonic development. On the other hand, maternal diabetes is associated with changes in miRNA both in maternal and in foetal tissues. This review aims to summarise the existing knowledge on miRNAs in gestational and pre-gestational diabetes, both as diagnostic biomarkers and as mechanistic players, in the development of gestational diabetes itself and also of short- and long-term complications for the mother and her offspring.
URI: http://hdl.handle.net/10553/55021
ISSN: 2311-553X
DOI: 10.3390/ncrna4040032
Fuente: Non-coding RNA [ISSN 2311-553X], v. 4 (32), (Noviembre 2018)
Colección:Reseña
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