Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/48428
Título: Flavonoids from eupatorium illitum and their antiproliferative activities
Autores/as: Castillo, Quírico A.
Triana, Jorge
Eiroa, José L. 
Padrón, José M.
Plata, Gabriela B.
Abel-Santos, Ernesto V.
Báez, Luis A.
Rodríguez, Diana C.
Jiménez, Marco A.
Pérez-Pujols, María F.
Clasificación UNESCO: 32 Ciencias médicas
3208 Farmacodinámica
Palabras clave: Eupatorium illitum
Ermanin
4-Hydroxybenzoic acid
Kumatakenin
7-Methoxy-aromadendrin, et al.
Fecha de publicación: 2015
Publicación seriada: Pharmacognosy Journal 
Resumen: To isolate the chemical constituents of the aerial parts from Eupatorium illitum, elucidate their structures and evaluate their antiproliferative activity on human cancer cell lines. Materials and Methods: The ethanolic extract of Eupatorium illitum afforded five compounds, which were characterized using spectroscopic techniques and by comparison with data from the literature. Antiproliferative activities of selected isolates were evaluated. Results: The flavonoids Kumatakenin (1), Ermanin (2), 7-methoxy-aromadendrin (3) and Naringenin (4), together with 4-hydroxybenzoic acid (5) were isolated. Compounds 1, 2, 4 and 5 were evaluated for their antiproliferative activity on the human cancer cell lines A549 (lung), HBL-100 (breast), HeLa (cervix), SW1573 (lung), and T-47D (breast) presenting a wide range of bioactivities. In general, best results were observed for 5. Conclusion: Compounds 1-5 are reported for first time from Eupatorium illitum. Isolated phytochemicals show moderate to low antiproliferative activities when evaluated on the aforementioned human cancer cell lines.
URI: http://hdl.handle.net/10553/48428
ISSN: 0975-3575
DOI: 10.5530/pj.2015.3.6
Fuente: Pharmacognosy Journal [0975-3575], v. 7 (3), p. 178-181
Colección:Artículos
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