Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/77937
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dc.contributor.authorWall, Samantha K.en_US
dc.contributor.authorWellnitz, Olgaen_US
dc.contributor.authorHernández Castellano, Lorenzo Enriqueen_US
dc.contributor.authorAhmadpour, Amiren_US
dc.contributor.authorBruckmaier, Rupert M.en_US
dc.date.accessioned2021-03-04T13:50:47Z-
dc.date.available2021-03-04T13:50:47Z-
dc.date.issued2016en_US
dc.identifier.issn0022-0302en_US
dc.identifier.urihttp://hdl.handle.net/10553/77937-
dc.description.abstractBacterial mastitis causes pathogen-dependent changes of the blood-milk barrier, and these changes can influence the differential transfer of blood components to milk. It is well known that gram-negative pathogens such as Escherichia coli can cause a greater activation of the immune system and thus a more comprehensive transfer of blood components including IgG than gram-positive pathogens such as Staphylococcus aureus. Supraphysiological doses of oxytocin (OT) have been shown to increase the permeability of the blood-milk barrier; however, the effect of OT during experimentally induced mastitis has not been investigated. Therefore, the objective of this study was to examine if intravenous administration of OT during lipopolysaccharide (LPS)- or lipoteichoic acid (LTA)-induced mastitis could influence the transfer of blood components to milk. The hypothesis was that OT could induce a greater transfer of blood components during mastitis. Twenty-seven dairy cows were injected via the teat canal with LPS, LTA, or a saline control followed by an intravenous injection of OT 2 h following intramammary challenge. Milk samples were collected every half hour and analyzed for somatic cell count (SCC), IgG, lactate dehydrogenase (LDH), and serum albumin (SA). Due to the chosen dosage of LPS and LTA, there was no difference in SCC between quarters challenged with only LPS or LTA. Quarters challenged with LPS and OT had a higher SCC and a greater transfer of IgG, LDH, and SA compared with quarters challenged with only LPS. Quarters challenged with LTA and OT had a greater transfer of IgG, LDH, and SA, whereas the SCC increase did not differ from quarters only treated with LTA. In quarters treated only with OT, SCC, LDH, and SA increased, but no difference was observed in IgG concentration from untreated control quarters. In conclusion, there are pathogen-specific changes in the blood-milk barrier and OT can induce a greater transfer of blood components to milk in both LPS- and LTA-induced mastitis. Oxytocin could have implications for use as a mastitis therapy, as there was an increased transfer of IgG into the milk.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Dairy Scienceen_US
dc.sourceJournal of Dairy Science [ISSN 0022-0302], v. 99(11), p. 9165-9173en_US
dc.subject3104 Producción Animalen_US
dc.subject.otherMastitisen_US
dc.subject.otherBlood-milk barrieren_US
dc.subject.otherEndotoxinen_US
dc.subject.otherOxytocinen_US
dc.titleSupraphysiological oxytocin increases the transfer of immunoglobulins and other blood components to milk during lipopolysaccharide- and lipoteichoic acid–induced mastitis in dairy cowsen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typearticleen_US
dc.identifier.doi10.3168/jds.2016-11548en_US
dc.identifier.issue11-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.utils.revisionen_US
dc.identifier.ulpgcNoen_US
dc.contributor.buulpgcBU-VETen_US
dc.description.sjr1,304
dc.description.jcr2,474
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptGIR IUSA-ONEHEALTH 4. Producción y Biotecnología Animal-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.orcid0000-0003-2729-0434-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.fullNameHernández Castellano, Lorenzo Enrique-
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