Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/77934
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dc.contributor.authorHernández Castellano, Lorenzo Enriqueen_US
dc.contributor.authorHernandez, Laura L.en_US
dc.contributor.authorWeaver, Samanthaen_US
dc.contributor.authorBruckmaier, Rupert M.en_US
dc.date.accessioned2021-03-04T13:40:08Z-
dc.date.available2021-03-04T13:40:08Z-
dc.date.issued2017en_US
dc.identifier.issn0022-0302en_US
dc.identifier.urihttp://hdl.handle.net/10553/77934-
dc.description.abstractHypocalcemia in dairy cows is caused by the sudden increase in calcium demand by the mammary gland for milk production at the onset of lactation. Serotonin (5-HT) is a key factor for calcium homeostasis, modulating calcium concentration in blood. Therefore, it is hypothesized that administration of 5-hydroxy-l-tryptophan (5-HTP), a 5-HT precursor, can increase 5-HT concentrations in blood and, in turn, induce an increase in blood calcium concentration. In this study, 20 Holstein dairy cows were randomly assigned to 2 experimental groups. Both groups received a daily i.v. infusion of 1 L of either 0.9% NaCl (C group; n = 10) or 0.9% NaCl containing 1 mg of 5-HTP/kg of BW (5-HTP group, n = 10). Infusions started d 10 before the estimated parturition and ceased the day of parturition, resulting in at least 4 d of infusion (8.37 ± 0.74 d of infusion). Until parturition, blood samples were collected every morning before the infusions, after parturition samples were taken daily until d 7, and a final sample was collected on d 30. Milk yield was recorded during this period. No differences between groups were observed for blood glucose, magnesium, and β-hydroxybutyrate. Cows receiving the 5-HTP infusion showed an increase in fatty acid concentrations from d -3 to -1 before parturition. Serum 5-HT concentrations were increased at d -4 related to parturition until d 5 postpartum in the 5-HTP group compared with the C group. In addition, cows from the 5-HTP group had increased 5-HT concentrations in colostrum, but not in mature milk, on d 7 postpartum. Serum calcium concentrations decreased in both groups around parturition; however, calcium remained higher in the 5-HTP group than in controls, with a significant difference between groups on d 1 (1.62 ± 0.08 vs. 1.93 ± 0.09 mmol/L in control and 5-HTP groups, respectively) and d 2 (1.83 ± 0.06 vs. 2.07 ± 0.07 mmol/L in control and 5-HTP groups, respectively). Additionally, colostrum yield (first milking) was lower in the 5-HTP group compared with the C group, but without consequences on colostrum IgG concentrations. Milk yield did not differ between groups during the rest of the experiment. The study data were consistent with the concept that infusion of 5-HTP to dairy cows increases blood 5-HT concentrations, which in turn is a significant regulatory component in the chain of effectors that affect calcium status around parturition, hence the occurrence of clinical or subclinical hypocalcemia.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Dairy Scienceen_US
dc.sourceJournal of Dairy Science [ISSN 0022-0302], v. 100(2), p. 1580-1587en_US
dc.subject3104 Producción Animalen_US
dc.subject.other5-hydroxy-l-tryptophanen_US
dc.subject.otherCalciumen_US
dc.subject.otherHypocalcemiaen_US
dc.subject.otherSerotoninen_US
dc.titleIncreased serum serotonin improves parturient calcium homeostasis in dairy cowsen_US
dc.typeArticleen_US
dc.identifier.doi10.3168/jds.2016-11638en_US
dc.identifier.issue2-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.utils.revisionen_US
dc.identifier.ulpgcNoen_US
dc.contributor.buulpgcBU-VETen_US
dc.description.sjr1,35
dc.description.jcr2,749
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptProducción y Biotecnología Animal-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.orcid0000-0003-2729-0434-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.fullNameHernández Castellano, Lorenzo Enrique-
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