Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/77456
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dc.contributor.authorPapandreou, Christopheren_US
dc.contributor.authorBulló, Mònicaen_US
dc.contributor.authorHernández-Alonso, Pabloen_US
dc.contributor.authorRuiz-Canela, Miguelen_US
dc.contributor.authorLi, Junen_US
dc.contributor.authorGuasch-Ferré, Martaen_US
dc.contributor.authorToledo, Estefaníaen_US
dc.contributor.authorClish, Claryen_US
dc.contributor.authorCorella, Doloresen_US
dc.contributor.authorEstruch, Ramonen_US
dc.contributor.authorRos, Emilioen_US
dc.contributor.authorFitó, Montserraten_US
dc.contributor.authorAlonso-Gómez, Angelen_US
dc.contributor.authorFiol, Miquelen_US
dc.contributor.authorSantos-Lozano, José M.en_US
dc.contributor.authorSerra Majem, Luisen_US
dc.contributor.authorLiang, Limingen_US
dc.contributor.authorMartínez-González, Miguel A.en_US
dc.contributor.authorHu, Frank B.en_US
dc.contributor.authorSalas-Salvadó, Jordien_US
dc.date.accessioned2021-02-02T11:10:53Z-
dc.date.available2021-02-02T11:10:53Z-
dc.date.issued2021en_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/77456-
dc.description.abstractBACKGROUND: Few studies have examined the associations of trimethylamine-N-oxide (TMAO) and its precursors (choline, betaine, dimethylglycine, and L-carnitine) with the risk of atrial fibrillation (AF) and heart failure (HF). This study sought to investigate these associations. METHODS: Prospective associations of these metabolites with incident AF and HF were examined among participants at high cardiovascular risk in the PREDIMED study (PREvención con DIeta MEDiterránea) after follow-up for about 10 years. Two nested case-control studies were conducted, including 509 AF incident cases matched to 618 controls and 326 HF incident cases matched to 426 controls. Plasma levels of TMAO and its precursors were semi-quantitatively profiled with liquid chromatography tandem mass spectrometry. Odds ratios were estimated with multivariable conditional logistic regression models. RESULTS: After adjustment for classical risk factors and accounting for multiple testing, participants in the highest quartile vs. the lowest quartile of baseline choline and betaine levels had a higher risk of AF [OR (95% CI): 1.85 (1.30-2.63) and 1.57 (1.09-2.24), respectively]. The corresponding OR for AF for extreme quartiles of dimethylglycine was 1.39 (0.99-1.96). One SD increase in log-transformed dimethylglycine was positively associated with AF risk (OR, 1.17; 1.03-1.33). The corresponding ORs for HF for extreme quartiles of choline, betaine, and dimethylglycine were 2.51 (1.57-4.03), 1.65 (1.00-2.71) and 1.65 (1.04-2.61), respectively. TMAO and L-carnitine levels were not associated with AF or HF. CONCLUSIONS: Our findings support the role of the choline metabolic pathway in the pathogenesis of AF and HF.en_US
dc.languageengen_US
dc.relation.ispartofClinical chemistry (Baltimore, Md.)en_US
dc.sourceClinical chemistry [EISSN 1530-8561], v. 67 (1), p. 288-297, (Enero 2021)en_US
dc.subject320501 Cardiologíaen_US
dc.subject.otherAtrial Fibrillationen_US
dc.subject.otherCholine Metabolismen_US
dc.subject.otherHeart Failureen_US
dc.subject.otherPredimeden_US
dc.subject.otherTrimethylamine-N-Oxideen_US
dc.titleCholine metabolism and risk of atrial fibrillation and heart failure in the PREDIMED Studyen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1093/clinchem/hvaa224en_US
dc.identifier.scopus85099721451-
dc.contributor.authorscopusid36470858000-
dc.contributor.authorscopusid6602243634-
dc.contributor.authorscopusid56239477300-
dc.contributor.authorscopusid6603417884-
dc.contributor.authorscopusid55872143100-
dc.contributor.authorscopusid55110459200-
dc.contributor.authorscopusid7003562288-
dc.contributor.authorscopusid35460787900-
dc.contributor.authorscopusid57190234196-
dc.contributor.authorscopusid57203178072-
dc.contributor.authorscopusid57202569537-
dc.contributor.authorscopusid57214985386-
dc.contributor.authorscopusid7004308784-
dc.contributor.authorscopusid57213577716-
dc.contributor.authorscopusid6602779360-
dc.contributor.authorscopusid35596972100-
dc.contributor.authorscopusid57216597824-
dc.contributor.authorscopusid7004290629-
dc.contributor.authorscopusid57208121316-
dc.contributor.authorscopusid57206277408-
dc.identifier.eissn1530-8561-
dc.description.lastpage297en_US
dc.identifier.issue1-
dc.description.firstpage288en_US
dc.relation.volume67en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.utils.revisionen_US
dc.date.coverdateEnero 2021en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,785
dc.description.jcr12,167
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Nutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0002-9658-9061-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSerra Majem, Luis-
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