Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/77023
Campo DC Valoridioma
dc.contributor.authorCastro-Barquero, Saraen_US
dc.contributor.authorRibó-Coll, Margaritaen_US
dc.contributor.authorLassale, Camilleen_US
dc.contributor.authorTresserra-Rimbau, Annaen_US
dc.contributor.authorCastañer, Olgaen_US
dc.contributor.authorPintó, Xavieren_US
dc.contributor.authorMartínez-González, Miguel Ángelen_US
dc.contributor.authorSorlí, José V.en_US
dc.contributor.authorSalas-Salvadó, Jordien_US
dc.contributor.authorLapetra, Joséen_US
dc.contributor.authorGómez-Gracia, Enriqueen_US
dc.contributor.authorAlonso-Gómez, Ángel M.en_US
dc.contributor.authorFiol, Miquelen_US
dc.contributor.authorSerra Majem, Luisen_US
dc.contributor.authorSacanella, Emilioen_US
dc.contributor.authorBasterra-Gortari, Francisco Javieren_US
dc.contributor.authorPortolés, Olgaen_US
dc.contributor.authorBabio, Nancyen_US
dc.contributor.authorCofán, Montserraten_US
dc.contributor.authorRos, Emilioen_US
dc.contributor.authorEstruch, Ramónen_US
dc.contributor.authorHernáez, Álvaroen_US
dc.date.accessioned2021-01-04T14:59:35Z-
dc.date.available2021-01-04T14:59:35Z-
dc.date.issued2020en_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/77023-
dc.description.abstractOur aim is to assess whether following a Mediterranean Diet (MedDiet) decreases the risk of initiating antithrombotic therapies and the cardiovascular risk associated with its use in older individuals at high cardiovascular risk. We evaluate whether participants of the PREvención con DIeta MEDiterránea (PREDIMED) study allocated to a MedDiet enriched in extra-virgin olive oil or nuts (versus a low-fat control intervention) disclose differences in the risk of initiation of: (1) vitamin K epoxide reductase inhibitors (acenocumarol/warfarin; n = 6772); (2) acetylsalicylic acid as antiplatelet agent (n = 5662); and (3) other antiplatelet drugs (cilostazol/clopidogrel/dipyridamole/ditazol/ticlopidine/triflusal; n = 6768). We also assess whether MedDiet modifies the association between the antithrombotic drug baseline use and incident cardiovascular events. The MedDiet intervention enriched with extra-virgin olive oil decreased the risk of initiating the use of vitamin K epoxide reductase inhibitors relative to control diet (HR: 0.68 [0.46–0.998]). Their use was also more strongly associated with an increased risk of cardiovascular disease in participants not allocated to MedDiet interventions (HRcontrol diet: 4.22 [1.92–9.30], HRMedDiets: 1.71 [0.83–3.52], p-interaction = 0.052). In conclusion, in an older population at high cardiovascular risk, following a MedDiet decreases the initiation of antithrombotic therapies and the risk of suffering major cardiovascular events among users of vitamin K epoxide reductase inhibitors.en_US
dc.languageengen_US
dc.relation.ispartofNutrientsen_US
dc.sourceNutrients [EISSN 2072-6643],v. 12 (12), p. 1-14, (Diciembre 2020)en_US
dc.subject32 Ciencias médicasen_US
dc.subject3206 Ciencias de la nutriciónen_US
dc.subject.other4-Hydroxycoumarinsen_US
dc.subject.otherMediterranean Dieten_US
dc.subject.otherPlatelet Aggregation Inhibitorsen_US
dc.subject.otherPreventionen_US
dc.subject.otherRandomized Controlled Trialsen_US
dc.titleMediterranean diet decreases the initiation of use of vitamin k epoxide reductase inhibitors and their associated cardiovascular risk: A randomized controlled trialen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/nu12123895en_US
dc.identifier.scopus85098259145-
dc.contributor.authorscopusid57202727634-
dc.contributor.authorscopusid57204722195-
dc.contributor.authorscopusid35798512000-
dc.contributor.authorscopusid55510803900-
dc.contributor.authorscopusid36487707800-
dc.contributor.authorscopusid57214783328-
dc.contributor.authorscopusid7004290629-
dc.contributor.authorscopusid7004605575-
dc.contributor.authorscopusid7003357665-
dc.contributor.authorscopusid6507771144-
dc.contributor.authorscopusid57202571697-
dc.contributor.authorscopusid7004308784-
dc.contributor.authorscopusid7005315313-
dc.contributor.authorscopusid35596972100-
dc.contributor.authorscopusid7003691118-
dc.contributor.authorscopusid16306349400-
dc.contributor.authorscopusid6603006074-
dc.contributor.authorscopusid24279242400-
dc.contributor.authorscopusid6602419864-
dc.contributor.authorscopusid57202569537-
dc.contributor.authorscopusid7005989830-
dc.contributor.authorscopusid55916184000-
dc.identifier.eissn2072-6643-
dc.description.lastpage14en_US
dc.identifier.issue12-
dc.description.firstpage1en_US
dc.relation.volume12en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages15en_US
dc.utils.revisionen_US
dc.date.coverdateDiciembre 2020en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,418
dc.description.jcr5,717
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Nutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0002-9658-9061-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSerra Majem, Luis-
Colección:Artículos
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