Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/77021
Campo DC Valoridioma
dc.contributor.authorFont-Díaz, Joanen_US
dc.contributor.authorJiménez-Panizo, Albaen_US
dc.contributor.authorCaelles, Carmeen_US
dc.contributor.authorVivanco, María d.M.en_US
dc.contributor.authorPérez, Palomaen_US
dc.contributor.authorAranda, Anaen_US
dc.contributor.authorEstébanez-Perpiñá, Evaen_US
dc.contributor.authorCastrillo Viguera, Antonio Jesúsen_US
dc.contributor.authorRicote, Mercedesen_US
dc.contributor.authorValledor, Annabel F.en_US
dc.date.accessioned2021-01-04T14:51:44Z-
dc.date.available2021-01-04T14:51:44Z-
dc.date.issued2021en_US
dc.identifier.issn1044-579Xen_US
dc.identifier.otherScopus-
dc.identifier.otherWoS-
dc.identifier.urihttp://hdl.handle.net/10553/77021-
dc.description.abstractNuclear receptors (NRs) are a superfamily of ligand-activated transcription factors that act as biological sensors and use a combination of mechanisms to modulate positively and negatively gene expression in a spatial and temporal manner. The highly orchestrated biological actions of several NRs influence the proliferation, differentiation, and apoptosis of many different cell types. Synthetic ligands for several NRs have been the focus of extensive drug discovery efforts for cancer intervention. This review summarizes the roles in tumour growth and metastasis of several relevant NR family members, namely androgen receptor (AR), estrogen receptor (ER), glucocorticoid receptor (GR), thyroid hormone receptor (TR), retinoic acid receptors (RARs), retinoid X receptors (RXRs), peroxisome proliferator-activated receptors (PPARs), and liver X receptors (LXRs). These studies are key to develop improved therapeutic agents based on novel modes of action with reduced side effects and overcoming resistance.en_US
dc.languageengen_US
dc.relation.ispartofSeminars in Cancer Biologyen_US
dc.sourceSeminars In Cancer Biology [ISSN 1044-579X], v. 73, p. 58-75, (Agosto 2021)en_US
dc.subject32 Ciencias médicasen_US
dc.subject320101 Oncologíaen_US
dc.subject.otherApoptosisen_US
dc.subject.otherCanceren_US
dc.subject.otherMetastasisen_US
dc.subject.otherNuclear Receptoren_US
dc.subject.otherProliferationen_US
dc.titleNuclear receptors: Lipid and hormone sensors with essential roles in the control of cancer developmenten_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.semcancer.2020.12.007en_US
dc.identifier.scopus85098157169-
dc.identifier.isi000661248600006-
dc.contributor.authorscopusid57221090517-
dc.contributor.authorscopusid57209821526-
dc.contributor.authorscopusid6701453184-
dc.contributor.authorscopusid6603734493-
dc.contributor.authorscopusid7201902660-
dc.contributor.authorscopusid57204744730-
dc.contributor.authorscopusid8303630600-
dc.contributor.authorscopusid55445301000-
dc.contributor.authorscopusid6701701296-
dc.contributor.authorscopusid6602429316-
dc.identifier.eissn1096-3650-
dc.description.lastpage75en_US
dc.description.firstpage58en_US
dc.relation.volume73en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid43081153-
dc.contributor.daisngid44015523-
dc.contributor.daisngid712984-
dc.contributor.daisngid44436703-
dc.contributor.daisngid44091036-
dc.contributor.daisngid34781599-
dc.contributor.daisngid42301666-
dc.contributor.daisngid41802755-
dc.contributor.daisngid667239-
dc.contributor.daisngid1019812-
dc.description.numberofpages18en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Font-Diaz, J-
dc.contributor.wosstandardWOS:Jimenez-Panizo, A-
dc.contributor.wosstandardWOS:Caelles, C-
dc.contributor.wosstandardWOS:Vivanco, MD-
dc.contributor.wosstandardWOS:Perez, P-
dc.contributor.wosstandardWOS:Aranda, A-
dc.contributor.wosstandardWOS:Estebanez-Perpina, E-
dc.contributor.wosstandardWOS:Castrillo, A-
dc.contributor.wosstandardWOS:Ricote, M-
dc.contributor.wosstandardWOS:Valledor, AF-
dc.date.coverdateAgosto 2021en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr2,91
dc.description.jcr17,012
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
dc.description.miaricds11,0
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.orcid0000-0002-2057-2159-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameCastrillo Viguera,Antonio Jesús-
Colección:Artículos
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