Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/76825
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dc.contributor.authorNavarro, E.en_US
dc.contributor.authorAlonso, S. J.en_US
dc.contributor.authorNavarro, R.en_US
dc.contributor.authorTrujillo, J.en_US
dc.contributor.authorJorge, E.en_US
dc.date.accessioned2020-12-18T13:19:13Z-
dc.date.available2020-12-18T13:19:13Z-
dc.date.issued2006en_US
dc.identifier.issn1007-9327en_US
dc.identifier.otherWoS-
dc.identifier.urihttp://hdl.handle.net/10553/76825-
dc.description.abstractAIM: To study the effects of elenoside, an arylnaphthalene lignan from Justicia hyssopifolia, on gastrointestinal motility in vivo and in vitro in rats.METHODS: Routine in vivo experimental assessments were catharsis index, water percentage of boluses, intestinal transit, and codeine antagonism. The groups included were vehicle control (propylene glycol-ethanol-plant oil-tween 80), elenoside (i.p. 25 and 50 mg/kg), cisapride (i.p. 10 mg/kg), and codeine phosphate (intragastric route, 50 mg/kg). In vitro approaches used isolated rat intestinal tissues (duodenum, jejunum, and ileum). The effects of elenoside at concentrations of 3.2 x 10(-4), 6.4 x 10(-4) and 1.2 x 10(-3) mol/L, and cisapride at 10(-6) mol/L were investigated.RESULTS: Elenoside in vivo produced an increase in the catharsis index and water percentage of boluses and in the percentage of distance traveled by a suspension of activated charcoal. Codeine phosphate antagonized the effect of 25 mg/kg of elenoside. In vitro, elenoside in duodenum, jejunum and ileum produced an initial decrease in the contraction force followed by an increase. Elenoside resulted in decreased intestinal frequency in duodenum, jejunum, and ileum. The In vitro and in vivo effects of elenoside were similar to those produced by cisapride.CONCLUSION: Elenoside is a lignan with an action similar to that of purgative and prokinetics drugs. Elenoside, could be an alternative to cisapride in treatment of gastrointestinal diseases as well as a preventive therapy for the undesirable gastrointestinal effects produced by opioids used for mild to moderate pain.en_US
dc.languageengen_US
dc.relation.ispartofWorld Journal of Gastroenterologyen_US
dc.sourceWorld Journal of Gastroenterology [ISSN 1007-9327], v. 12 (44), p. 7143-7148, 2006en_US
dc.subject320503 Gastroenterologíaen_US
dc.subject.otherGastrointestinal motilityen_US
dc.subject.otherElenosideen_US
dc.subject.otherSmall Intestine Preparationen_US
dc.titleElenoside increases intestinal motilityen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.3748/wjg.v12.i44.7143en_US
dc.identifier.pmid17131476-
dc.identifier.scopus33845454333-
dc.identifier.isi000242527600011-
dc.contributor.authorscopusid56273603700-
dc.contributor.authorscopusid7102615168-
dc.contributor.authorscopusid7202829137-
dc.contributor.authorscopusid7103051162-
dc.contributor.authorscopusid6701783595-
dc.identifier.eissn2219-2840-
dc.description.lastpage7148en_US
dc.identifier.issue44-
dc.identifier.pmcidPMC4087775-
dc.description.firstpage7143en_US
dc.relation.volume12en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid1970623-
dc.contributor.daisngid1674878-
dc.contributor.daisngid5501662-
dc.contributor.daisngid34945025-
dc.contributor.daisngid9118786-
dc.description.numberofpages6en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Navarro, E-
dc.contributor.wosstandardWOS:Alonso, SJ-
dc.contributor.wosstandardWOS:Navarro, R-
dc.contributor.wosstandardWOS:Trujillo, J-
dc.contributor.wosstandardWOS:Jorge, E-
dc.date.coverdateNoviembre 2006en_US
dc.identifier.ulpgcen_US
dc.description.scieSCIE
item.fulltextCon texto completo-
item.grantfulltextopen-
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