Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/76579
DC FieldValueLanguage
dc.contributor.authorMartín de las Mulas, J.en_US
dc.contributor.authorEspinosa De Los Monteros Y Zayas, Antonioen_US
dc.contributor.authorBautista, M. J.en_US
dc.contributor.authorGómez Villamandos, J. C.en_US
dc.contributor.authorMorales, C.en_US
dc.date.accessioned2020-12-11T16:45:01Z-
dc.date.available2020-12-11T16:45:01Z-
dc.date.issued1994en_US
dc.identifier.issn0021-9975en_US
dc.identifier.otherWoS-
dc.identifier.urihttp://hdl.handle.net/10553/76579-
dc.description.abstractThirty-seven feline and 38 human spontaneous mammary gland carcinomas were studied immunohistochemically. Commercially available antibodies directed against high and low molecular weight keratins (RCK-102 and NCL-5D3), vimentin, desmin, glial fibrillary acidic protein (GFAP), neurofilament (NF) proteins and muscle actin (HHF35) were used in the avidin biotin peroxidase complex (ABC) technique on formalin-fixed paraffin wax-embedded tumour tissue samples. Healthy feline and human mammary gland tissue adjacent to the neoplasms was also examined. The distribution pattern of intermediate filament proteins and muscle actin was comparable in healthy mammary gland tissue of the two species: both RCK-102 and NCL-5D3 antibodies reacted with luminal epithelial cells of ducts and acini, but basal/ myoepithelial cells were stained by RCK-102 exclusively. In addition, basal/ myoepithelial cells expressed vimentin and muscle actin in,both species, and GFAP was found in some feline basal/myoepithelial cells. No immunoreactivity to desmin and NF proteins;was observed. Feline mammary gland carcinoma cells reacted with RCK-102 (89%), NCL-5D3 (62%), vimentin (76%) and GFAP (30%) antibodies, while human mammary gland carcinoma cells reacted with RCK-102 (95%), NCL-5D3 (100%) and vimentin (13%) antibodies. HHF35 immunoreactivity was observed in stromal cells only. These results indicate that mammary gland carcinomas of both species share a heterogeneous immunophenotype with respect to intermediate filament proteins, which adds to the list of known similarities between mammary gland carcinomas of both species.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Comparative Pathologyen_US
dc.sourceJournal of Comparative Pathology [ISSN 0021-9975], v. 111 (4), p. 365-381, (Noviembre 1994)en_US
dc.subject240111 Patología animalen_US
dc.subject320705 Patología comparativaen_US
dc.subject.otherExpressionen_US
dc.subject.otherCytokeratinsen_US
dc.subject.otherTissueen_US
dc.titleImmunohistochemical distribution pattern of intermediate filament proteins and muscle actin in feline and human mammary carcinomasen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/S0021-9975(05)80095-7en_US
dc.identifier.pmid7533801-
dc.identifier.scopus0028568648-
dc.identifier.isiA1994PV06400003-
dc.contributor.authorscopusid57211742924-
dc.contributor.authorscopusid36928058400-
dc.contributor.authorscopusid7006592846-
dc.contributor.authorscopusid7005937887-
dc.contributor.authorscopusid7202530931-
dc.identifier.eissn1532-3129-
dc.description.lastpage381en_US
dc.identifier.issue4-
dc.description.firstpage365en_US
dc.relation.volume111en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid407245-
dc.contributor.daisngid700159-
dc.contributor.daisngid571008-
dc.contributor.daisngid450041-
dc.contributor.daisngid30448294-
dc.description.numberofpages17en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:DELASMULAS, JM-
dc.contributor.wosstandardWOS:DELOSMONTEROS, AE-
dc.contributor.wosstandardWOS:BAUTISTA, MJ-
dc.contributor.wosstandardWOS:GOMEZVILLAMANDOS, JC-
dc.contributor.wosstandardWOS:MORALES, C-
dc.date.coverdateEnero 1994en_US
dc.identifier.ulpgcen_US
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR Histología y Patología Veterinaria-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.orcid0000-0002-7736-3139-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.fullNameEspinosa De Los Monteros Y Zayas, Antonio-
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