Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/76434
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dc.contributor.authorMartínez Quintana, Efrénen_US
dc.contributor.authorSánchez-Matos, Michelle Maríaen_US
dc.contributor.authorEstupiñán-León, Hiurmaen_US
dc.contributor.authorRojas-Brito, Ana Beatrizen_US
dc.contributor.authorGonzález-Martín, Jesús Maríaen_US
dc.contributor.authorRodríguez-González, Faynaen_US
dc.contributor.authorTugores, Antonioen_US
dc.date.accessioned2020-12-09T10:11:10Z-
dc.date.available2020-12-09T10:11:10Z-
dc.date.issued2021en_US
dc.identifier.issn0939-4753en_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/76434-
dc.description.abstractThe Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II UniversityBackground and aims: Malnutrition is found frequently during chronic diseases, and its prevalence and relation to disease outcome in adult patients with congenital heart disease (CHD) remains unknown. Methods and results: A cohort of 393 consecutive stable congenital heart disease (CHD) patients was followed up in a single dedicated clinical unit. Demographic, clinical and laboratory parameters, along with a nutritional risk index (NRI), were studied, as well as major acute cardiovascular events (MACE), defined as arterial thrombotic events, heart failure requiring hospitalization or cardiovascular and non-cardiovascular mortality. The median age of the patients was 23 years (17–35) and 225 (57%) were males. Median plasma albumin concentration was 4.5 (4.2–4.7) g/dL, the body mass index was 23 (21–27) kg/m2, the NRI was 112 (106–118), and 33 (8%) patients showed malnutrition (NIR<100). A worse NYHA functional class (II and III), total cholesterol and serum glucose levels were significant risk factors associated with malnutrition (NRI<100) in CHD patients. During a median follow-up of 8 (5–10) years, 39 (10%) CHD patients suffered a MACE. Multivariable Cox regression analysis showed that older patients (years) [HR 1.06 (1.04–1.09), p < 0.001], CHD patients with great anatomical complexity [HR 4.24 (2.17–8.27), p < 0.001] and those with a lower NRI [HR 0.95 (0.93–0.98), p = 0.001] had a significant worse MACE-free survival, being the NRI a better predictor of MACE than albumin concentration. Conclusions: A low NRI is independently associated with a significant increased risk of MACE in CHD patients.en_US
dc.languageengen_US
dc.relation.ispartofNutrition, Metabolism and Cardiovascular Diseasesen_US
dc.sourceNutrition, Metabolism and Cardiovascular Diseases [ISSN 0939-4753], v. 31(8), p. 481-488en_US
dc.subject320501 Cardiologíaen_US
dc.subject320610 Enfermedades de la nutriciónen_US
dc.subject.otherCardiac Mortalityen_US
dc.subject.otherCongenital Heart Diseaseen_US
dc.subject.otherMalnutritionen_US
dc.subject.otherSurvivalen_US
dc.titleMalnutrition is independently associated with an increased risk of major cardiovascular events in adult patients with congenital heart diseaseen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.numecd.2020.09.026en_US
dc.identifier.scopus85096511062-
dc.contributor.authorscopusid23485891800-
dc.contributor.authorscopusid57220037881-
dc.contributor.authorscopusid57219315055-
dc.contributor.authorscopusid57220032087-
dc.contributor.authorscopusid57220033314-
dc.contributor.authorscopusid24825586600-
dc.contributor.authorscopusid6701671839-
dc.identifier.eissn1590-3729-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.utils.revisionen_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,013
dc.description.jcr4,666
dc.description.sjrqQ1
dc.description.jcrqQ2
dc.description.scieSCIE
dc.description.miaricds11,0
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.deptGIR IUIBS: Diabetes y endocrinología aplicada-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.orcid0000-0002-1849-9239-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameMartínez Quintana, Efrén-
crisitem.author.fullNameTugores Céster,Antonio-
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