Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/76422
Campo DC Valoridioma
dc.contributor.authorVorkamp, Katrinen_US
dc.contributor.authorCastaño, Argeliaen_US
dc.contributor.authorAntignac, Jean Philippeen_US
dc.contributor.authorDomínguez Boada, Luis Maríaen_US
dc.contributor.authorCequier, Enriqueen_US
dc.contributor.authorCovaci, Adrianen_US
dc.contributor.authorEsteban López, Martaen_US
dc.contributor.authorHaug, Line S.en_US
dc.contributor.authorKasper-Sonnenberg, Monikaen_US
dc.contributor.authorKoch, Holger M.en_US
dc.contributor.authorPérez Luzardo, Octavio Luisen_US
dc.contributor.authorOsīte, Agneseen_US
dc.contributor.authorRambaud, Loïcen_US
dc.contributor.authorPinorini, Maria Teresaen_US
dc.contributor.authorSabbioni, Gabrieleen_US
dc.contributor.authorThomsen, Cathrineen_US
dc.date.accessioned2020-12-09T09:25:39Z-
dc.date.available2020-12-09T09:25:39Z-
dc.date.issued2021en_US
dc.identifier.issn0160-4120en_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/76422-
dc.description.abstractThe major purpose of human biomonitoring is the mapping and assessment of human exposure to chemicals. The European initiative HBM4EU has prioritized seven substance groups and two metals relevant for human exposure: Phthalates and substitutes (1,2-cyclohexane dicarboxylic acid diisononyl ester, DINCH), bisphenols, per- and polyfluoroalkyl substances (PFASs), halogenated and organophosphorous flame retardants (HFRs and OPFRs), polycyclic aromatic hydrocarbons (PAHs), arylamines, cadmium and chromium. As a first step towards comparable European-wide data, the most suitable biomarkers, human matrices and analytical methods for each substance group or metal were selected from the scientific literature, based on a set of selection criteria. The biomarkers included parent compounds of PFASs and HFRs in serum, of bisphenols and arylamines in urine, metabolites of phthalates, DINCH, OPFRs and PAHs in urine as well as metals in blood and urine, with a preference to measure Cr in erythrocytes representing Cr (VI) exposure. High performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) was the method of choice for bisphenols, PFASs, the HFR hexabromocyclododecane (HBCDD), phenolic HFRs as well as the metabolites of phthalates, DINCH, OPFRs and PAHs in urine. Gas chromatographic (GC) methods were selected for the remaining compounds, e.g. GC-low resolution MS with electron capture negative ionization (ECNI) for HFRs. Both GC–MS and LC-MS/MS were suitable for arylamines. New developments towards increased applications of GC–MS/MS may offer alternatives to GC–MS or LC-MS/MS approaches, e.g. for bisphenols. The metals were best determined by inductively coupled plasma (ICP)-MS, with the particular challenge of avoiding interferences in the Cd determination in urine. The evaluation process revealed research needs towards higher sensitivity and non-invasive sampling as well as a need for more stringent quality assurance/quality control applications and assessments.en_US
dc.languageengen_US
dc.relation.ispartofEnvironment Internationalen_US
dc.sourceEnvironment International [ISSN 0160-4120], v. 146, 106082, (Enero 2021)en_US
dc.subject3214 Toxicologíaen_US
dc.subject.otherBisphenolsen_US
dc.subject.otherFlame Retardantsen_US
dc.subject.otherHBM4EUen_US
dc.subject.otherMetalsen_US
dc.subject.otherPer- And Polyfluoroalkyl Substancesen_US
dc.subject.otherPhthalatesen_US
dc.titleBiomarkers, matrices and analytical methods targeting human exposure to chemicals selected for a European human biomonitoring initiativeen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.envint.2020.106082en_US
dc.identifier.scopus85096701899-
dc.contributor.authorscopusid6603619920-
dc.contributor.authorscopusid7005340777-
dc.contributor.authorscopusid6603606674-
dc.contributor.authorscopusid6603916807-
dc.contributor.authorscopusid57210841813-
dc.contributor.authorscopusid7007134174-
dc.contributor.authorscopusid57194740758-
dc.contributor.authorscopusid23024655700-
dc.contributor.authorscopusid6503934034-
dc.contributor.authorscopusid35336917300-
dc.contributor.authorscopusid57219850582-
dc.contributor.authorscopusid48361792100-
dc.contributor.authorscopusid56079322000-
dc.contributor.authorscopusid6506205523-
dc.contributor.authorscopusid7004645833-
dc.contributor.authorscopusid15832890200-
dc.identifier.eissn1873-6750-
dc.relation.volume146en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.utils.revisionen_US
dc.date.coverdateEnero 2021en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr2,757
dc.description.jcr13,352
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
dc.description.miaricds11,0
item.fulltextCon texto completo-
item.grantfulltextopen-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0002-0195-4565-
crisitem.author.orcid0000-0002-4153-3028-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameDomínguez Boada, Luis María-
crisitem.author.fullNamePérez Luzardo, Octavio Luis-
Colección:Artículos
miniatura
Adobe PDF (676,01 kB)
Vista resumida

Citas SCOPUSTM   

76
actualizado el 24-mar-2024

Visitas

156
actualizado el 23-ene-2024

Descargas

197
actualizado el 23-ene-2024

Google ScholarTM

Verifica

Altmetric


Comparte



Exporta metadatos



Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.