Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/76258
DC FieldValueLanguage
dc.contributor.authorMaynar Moliner, Manuelen_US
dc.contributor.authorQian, Zen_US
dc.contributor.authorHernandez, Jen_US
dc.contributor.authorSun, Fen_US
dc.contributor.authorDeMiguel, Cen_US
dc.contributor.authorCrisostomo, Ven_US
dc.contributor.authorUson, Jen_US
dc.contributor.authorPineda, LFen_US
dc.contributor.authorEspinoza, CGen_US
dc.contributor.authorCastaneda, WRen_US
dc.date.accessioned2020-12-02T15:31:08Z-
dc.date.available2020-12-02T15:31:08Z-
dc.date.issued2003en_US
dc.identifier.issn0174-1551en_US
dc.identifier.otherWoS-
dc.identifier.urihttp://hdl.handle.net/10553/76258-
dc.description.abstractThe purpose of this study was to develop an abdominal aortic aneurysm model that more closely resembles the morphology of human aneurysms with potential for further growth of the sac. An infrarenal abdominal aortic aneurysm (AAA) model was created with a double-layered peritoneal patch in 27 domestic swine. The patch, measuring in average from 6 to 12 cm in length and from 2 to 3 cm in width, was sutured to the edge of an aortotomy. Pre- and postsurgical digital subtraction aortograms (DSA) were obtained to document the appearance and dimensions of the aneurysm. All animals were followed with DSA for up to 5 months. Laparoscopic examination enhanced by the use of laparoscopic ultrasound was also carried out in 2 animals to assess the aneurysm at 30 and 60 days following surgery. Histological examination was performed on 4 animals. All the animals that underwent the surgical creation of the AAA survived the surgical procedure. Postsurgical DSA demonstrated the presence of the AAA in all animals, defined as more than 50% increase in diameter. The aneurysmal mean diameter increased from the baseline of 10.27 +/- 1.24 to 16.69 +/- 2.29 mm immediately after surgery, to 27.6 +/- 6.59 mm at 14 days, 32.45 +/- 8.76 mm at 30 days (p < 0.01), and subsequently decreased to 25.98 +/- 3.75 mm at 60 days. A total of 15 animals died of aneurysmal rupture that occurred more frequently in the long aneurysms (greater than or equal to6 cm in length) than the short aneurysms (<6 cm in length) during the first 2 weeks after surgery (p < 0.05). No rupture occurred beyond 16 days after surgery. Four animals survived and underwent 60-day angiographic follow-up. Laparoscopic follow-up showed strong pulses, a reddish external appearance and undetectable suture lines on the aneurysmal wall. On pathology, the patches were well incorporated into the aortic wall, the luminal wall appeared almost completely endothelialized, and cellular and matrix proliferation were noted in the aneurysmal wall. A reproducible technique for the creation of an infrarenal AAA model was developed using a peritoneal patch in swine. The aneurysm model proved to have potential for further growth of the sac and a tendency to rupture. Because of the growth potential, this might be a better model than those with a noncompliant aneurysmal wall for the preclinical evaluation of stent-graft devices.en_US
dc.languageengen_US
dc.relation.ispartofCardioVascular and Interventional Radiologyen_US
dc.sourceCardiovascular And Interventional Radiology [ISSN 0174-1551], v. 26 (2), p. 168-176, (Marzo-Abril 2003)en_US
dc.subject32 Ciencias médicasen_US
dc.subject320704 Patología cardiovascularen_US
dc.subject.otherEndovascular Repairen_US
dc.subject.otherStent-Graftsen_US
dc.subject.otherFeasibilityen_US
dc.subject.otherExclusionen_US
dc.subject.otherWallen_US
dc.subject.otherAbdominal Wallen_US
dc.subject.otherAortic Aneurysmen_US
dc.subject.otherSwineen_US
dc.subject.otherAnatomical Modelen_US
dc.subject.otherPeritoneumen_US
dc.titleAn animal model of abdominal aortic aneurysm created with peritoneal patch: Technique and initial resultsen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s00270-002-2598-1en_US
dc.identifier.isi000183433400013-
dc.identifier.eissn1432-086X-
dc.description.lastpage176en_US
dc.identifier.issue2-
dc.description.firstpage168en_US
dc.relation.volume26en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid30319800-
dc.contributor.daisngid9731258-
dc.contributor.daisngid17279339-
dc.contributor.daisngid1483572-
dc.contributor.daisngid10006376-
dc.contributor.daisngid492319-
dc.contributor.daisngid527348-
dc.contributor.daisngid1900125-
dc.contributor.daisngid442193-
dc.contributor.daisngid1827169-
dc.description.numberofpages9en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Maynar, M-
dc.contributor.wosstandardWOS:Qian, Z-
dc.contributor.wosstandardWOS:Hernandez, J-
dc.contributor.wosstandardWOS:Sun, F-
dc.contributor.wosstandardWOS:DeMiguel, C-
dc.contributor.wosstandardWOS:Crisostomo, V-
dc.contributor.wosstandardWOS:Uson, J-
dc.contributor.wosstandardWOS:Pineda, LF-
dc.contributor.wosstandardWOS:Espinoza, CG-
dc.contributor.wosstandardWOS:Castaneda, WR-
dc.date.coverdateMarzo-Abril 2003en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr1,207
dc.description.jcrqQ3
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Tecnología Médica y Audiovisual-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.deptGIR TIDES: Economía, medioambiente, sostenibilidad y turismo-
crisitem.author.deptIU de Turismo y Desarrollo Económico Sostenible-
crisitem.author.deptDepartamento de Métodos Cuantitativos en Economía y Gestión-
crisitem.author.orcid0000-0001-9154-0712-
crisitem.author.orcid0000-0001-6897-5179-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Turismo y Desarrollo Económico Sostenible-
crisitem.author.fullNameMaynar Moliner, Manuel-
crisitem.author.fullNameHernández Guerra, Juan María-
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