Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/76134
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dc.contributor.authorCastañer, Olgaen_US
dc.contributor.authorPintó, Xavieren_US
dc.contributor.authorSubirana, Isaacen_US
dc.contributor.authorAmor, Antonio J.en_US
dc.contributor.authorRos, Emilioen_US
dc.contributor.authorHernáez, Álvaroen_US
dc.contributor.authorMartínez-González, Miguel Ángelen_US
dc.contributor.authorCorella, Doloresen_US
dc.contributor.authorSalas-Salvadó, Jordien_US
dc.contributor.authorEstruch, Ramónen_US
dc.contributor.authorLapetra, Joséen_US
dc.contributor.authorGómez-Gracia, Enriqueen_US
dc.contributor.authorAlonso-Gomez, Angel M.en_US
dc.contributor.authorFiol, Miquelen_US
dc.contributor.authorSerra Majem, Luisen_US
dc.contributor.authorCorbella, Emilien_US
dc.contributor.authorBenaiges, Daviden_US
dc.contributor.authorSorli, Jose V.en_US
dc.contributor.authorRuiz-Canela, Miguelen_US
dc.contributor.authorBabió, Nancyen_US
dc.contributor.authorSierra, Lucas Tojalen_US
dc.contributor.authorOrtega, Emilioen_US
dc.contributor.authorFitó, Montserraten_US
dc.date.accessioned2020-11-30T15:38:34Z-
dc.date.available2020-11-30T15:38:34Z-
dc.date.issued2020en_US
dc.identifier.issn0735-1097en_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/76134-
dc.description.abstractGenetic, observational, and clinical intervention studies indicate that circulating levels of triglycerides and cholesterol transported in triglyceride-rich lipoproteins (remnant cholesterol) can predict cardiovascular events. Objectives: This study evaluated the association of triglycerides and remnant cholesterol (remnant-C) with major cardiovascular events in a cohort of older individuals at high cardiovascular risk. Methods: This study determined the baseline lipid profile and searched for major adverse cardiovascular events (MACEs) in the high-risk primary prevention PREDIMED (Prevención con Dieta Mediterránea) trial population (mean age: 67 years; body mass index: 30 kg/m2; 43% men; 48% with diabetes) after a median follow-up of 4.8 years. Unadjusted and adjusted Cox proportional hazard models were used to assess the association between lipid concentrations (either as continuous or categorical variables) and incident MACEs (N = 6,901; n cases = 263). Results: In multivariable-adjusted analyses, triglycerides (hazard ratio [HR]: 1.04; 95% confidence interval [CI]: 1.02 to 1.06, per 10 mg/dl [0.11 mmol/l]; p < 0.001), non−high-density lipoprotein cholesterol (HDL-C) (HR: 1.05; 95% CI: 1.01 to 1.10, per 10 mg/dl [0.26 mmol/l]; p = 0.026), and remnant-C (HR: 1.21; 95% CI: 1.10 to 1.33, per 10 mg/dl [0.26 mmol/l]; p < 0.001), but not low-density lipoprotein cholesterol (LDL-C) or HDL-C, were associated with MACEs. Atherogenic dyslipidemia (triglycerides >150 mg/dl [1.69 mmol/l] and HDL-C <40 mg/dl [1.03 mmol/l] in men or <50 mg/dl [1.29 mmol/l] in women) was also associated with MACEs (HR: 1.44; 95% CI: 1.04 to 2.00; p = 0.030). Remnant-C ≥30 mg/dl (0.78 mmol/l) differentiated subjects at a higher risk of MACEs compared with those at lower concentrations, regardless of whether LDL-C levels were on target at ≤100 mg/dl (2.59 mmol/l). Conclusions: In overweight or obese subjects at high cardiovascular risk, levels of triglycerides and remnant-C, but not LDL-C, were associated with cardiovascular outcomes independent of other risk factors.en_US
dc.languageengen_US
dc.relation.ispartofJournal of the American College of Cardiologyen_US
dc.sourceJournal of the American College of Cardiology [ISSN 0735-1097], v. 76 (23), p. 2712-2724, (Diciembre 2020)en_US
dc.subject320501 Cardiologíaen_US
dc.subject.otherCardiovascular Diseaseen_US
dc.subject.otherNon−Hdl-Cholesterolen_US
dc.subject.otherRemnant Cholesterolen_US
dc.subject.otherTriglyceridesen_US
dc.titleRemnant cholesterol, not LDL cholesterol, is associated with incident cardiovascular diseaseen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.jacc.2020.10.008en_US
dc.identifier.scopus85096491398-
dc.contributor.authorscopusid36487707800-
dc.contributor.authorscopusid57214783328-
dc.contributor.authorscopusid57208764346-
dc.contributor.authorscopusid54419413900-
dc.contributor.authorscopusid35474202600-
dc.contributor.authorscopusid55916184000-
dc.contributor.authorscopusid7004290629-
dc.contributor.authorscopusid7003570538-
dc.contributor.authorscopusid7003357665-
dc.contributor.authorscopusid7005989830-
dc.contributor.authorscopusid6507771144-
dc.contributor.authorscopusid57202571697-
dc.contributor.authorscopusid7004308784-
dc.contributor.authorscopusid7005315313-
dc.contributor.authorscopusid35596972100-
dc.contributor.authorscopusid57175599500-
dc.contributor.authorscopusid6507262573-
dc.contributor.authorscopusid7004605575-
dc.contributor.authorscopusid6603417884-
dc.contributor.authorscopusid24279242400-
dc.contributor.authorscopusid57220007691-
dc.contributor.authorscopusid8281845100-
dc.contributor.authorscopusid6602891390-
dc.identifier.eissn1558-3597-
dc.description.lastpage2724en_US
dc.identifier.issue23-
dc.description.firstpage2712en_US
dc.relation.volume76en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages13en_US
dc.utils.revisionen_US
dc.date.coverdateDiciembre 2020en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr10,315
dc.description.jcr24,094
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Nutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0002-9658-9061-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSerra Majem, Luis-
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