Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/75699
Title: Development of a surface plasmon resonance and nanomechanical biosensing hybrid platform for multiparametric reading
Authors: Álvarez, Mar
Fariña, David
Medina Escuela, Alfonso Francisco 
Sendra Sendra, José Ramón 
Lechuga, Laura M.
UNESCO Clasification: 3325 Tecnología de las telecomunicaciones
Issue Date: 2013
Publisher: 0034-6748
Journal: Review of Scientific Instruments 
Abstract: We have developed a hybrid platform that combines two well-known biosensing technologies based on quite different transducer principles: surface plasmon resonance and nanomechanical sensing. The new system allows the simultaneous and real-time detection of two independent parameters, refractive index change (Delta n), and surface stress change (Delta sigma) when a biomolecular interaction takes place. Both parameters have a direct relation with the mass coverage of the sensor surface. The core of the platform is a common fluid cell, where the solution arrives to both sensor areas at the same time and under the same conditions (temperature, velocity, diffusion, etc.). The main objective of this integration is to achieve a better understanding of the physical behaviour of the transducers during sensing, increasing the information obtained in real time in one single experiment. The potential of the hybrid platform is demonstrated by the detection of DNA hybridization.
URI: http://hdl.handle.net/10553/52250
ISSN: 0034-6748
DOI: 10.1063/1.4789430
Source: Review Of Scientific Instruments[ISSN 0034-6748],v. 84 (1)
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